{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T23:38:39Z","timestamp":1778715519678,"version":"3.51.4"},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,10,31]],"date-time":"2020-10-31T00:00:00Z","timestamp":1604102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Topical \u03b2\u2010blockers, propranolol, and timolol were used for pyogenic granuloma (PG) treatment; however, their efficacies and safety profiles were not compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The aim was to evaluate the safety and efficacy of propranolol 1% and timolol 0.5% creams in the treatment of pyogenic granulomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>The study included 30 PG patients. They were divided into three groups (10 patients each). Group I patients received propranolol 1% cream. Group II patients used timolol 0.5% l cream. Group III patients used placebo cream. Creams were applied twice daily for 2\u00a0months. Patients were followed up for 3\u00a0months to detect any recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Complete resolution was reported in 6 patients of groups I and II, while none of the control patients reported complete resolution. Despite the absent change in lesions' size in 40% of \u03b2\u2010blockers treated groups, they all reported decreased bleeding tendency. There was insignificant difference between the clinical responses between \u03b2\u2010blockers groups. No recurrence was reported in any of the patients who achieved complete resolution after 3\u00a0months of follow\u2010up. Younger patients respond better to \u03b2\u2010blockers. Three patients were deteriorated on beta\u2010blockers treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>\u03b2\u2010blockers are a promising PG treatment option in cases where invasive modalities are not desirable especially in younger patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13800","type":"journal-article","created":{"date-parts":[[2020,10,31]],"date-time":"2020-10-31T12:15:55Z","timestamp":1604146555000},"page":"1801-1806","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Topical \u03b2\u2010blockers for pyogenic granulomas: A promising option for younger patients"],"prefix":"10.1111","volume":"20","author":[{"given":"Abd El\u2010Aziz Ibrahim","family":"El\u2010Taweel","sequence":"first","affiliation":[{"name":"Faculty of Medicine Benha University Benha Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdul\u2010Aziz Abdul\u2010Salam Ahmed","family":"Al\u2010Refaie","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Beni\u2010swif University Beni\u2010swif Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalid Hamdy Awad","family":"Salem","sequence":"additional","affiliation":[{"name":"Ministry of Health Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2805-1224","authenticated-orcid":false,"given":"Rehab Mohammed","family":"Salem","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Benha University Benha Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14740"},{"issue":"1","key":"e_1_2_8_3_1","first-page":"40","article-title":"Clinical inquiries. What's the best treatment for pyogenic granuloma?","volume":"59","author":"Gilmore A","year":"2010","journal-title":"J Fam Pract"},{"key":"e_1_2_8_4_1","first-page":"S277","volume-title":"The Pharmacological Basis of Therapeutics","author":"Westfall TC","year":"2010"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijdvl.IJDVL_220_16"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.13372"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12297"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13071"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.97655"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12217"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13116"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.13237"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0000000000001116"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2018.00605"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198403293101303"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.13800","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.13800","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.13800","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T11:34:36Z","timestamp":1692963276000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.13800"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,31]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1111\/jocd.13800"],"URL":"https:\/\/doi.org\/10.1111\/jocd.13800","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,31]]},"assertion":[{"value":"2020-08-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}