{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T21:54:32Z","timestamp":1788386072867,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T00:00:00Z","timestamp":1605052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although the etiopathogenesis of alopecia areata (AA) is still unclear, inflammation, oxidative stress, and subsequent DNA damage might be considered role players in disease development.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>We aimed at exploring the potential link between oxidative DNA damage and inflammation in AA patients through measuring 8\u2010hydroxy deoxyguanosine (8\u2010OHdG), high mobility group box 1 protein (HMGB1), and one of the inflammatory mediators, C\u2010reactive protein (CRP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 79 subjects (49 AA patients in addition to 30 apparently healthy control subjects) were tested for serum levels of 8\u2010OHdG, HMBG1, and CRP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with the control group, serum 8\u2010OHdG, HMBG1, and CRP levels were significantly elevated in the studied patients group (0.031, &lt;0.001, and &lt;0.001, respectively). Moreover, logistic regression analysis revealed that disease course, serum levels of 8\u2010OHdG, and HMBG1 were considered independent predictors for AA severity in both uni\u2010 and multivariable analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggest a possible role of oxidative stress together with proinflammatory biomarkers in development of AA and their benefit in predicting a severe form of the disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13814","type":"journal-article","created":{"date-parts":[[2020,10,25]],"date-time":"2020-10-25T12:11:38Z","timestamp":1603627898000},"page":"2305-2310","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Cross talk between oxidative stress and inflammation in alopecia areata"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3877-5787","authenticated-orcid":false,"given":"Amany Ibrahim","family":"Mustafa","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology Faculty of Medicine Benha University Benha Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rana Atef","family":"Khashaba","sequence":"additional","affiliation":[{"name":"Department of Clinical and Chemical Pathology Faculty of Medicine Benha University Benha Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman","family":"Fawzy","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Mansoura Fever Hospital Ministry of Health Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimaa Mohamad AbdElRahman","family":"Baghdady","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Molecular Biology Faculty of Medicine Benha University Benha Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shymaa Mostafa","family":"Rezk","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology Faculty of Medicine Benha University Benha Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.123494"},{"key":"e_1_2_11_3_1","first-page":"397","article-title":"Epidemiology and burden of alopecia areata: a systematic review","volume":"8","author":"Villasante Fricke AC","year":"2015","journal-title":"Clin Cosmetic Invest Dermatol"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/jidsymp.2013.4"},{"key":"e_1_2_11_5_1","first-page":"43","article-title":"Oxidative stress and alopecia areata","volume":"8","author":"Prie B","year":"2015","journal-title":"J Med Life"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700340"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(99)00123-8"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2007.06.029"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18112238"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2013.00164"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2011.01415.x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.55430"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/2319-4170.104408"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2010.3356"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12144"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.12054"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10517-011-1224-0"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2010.07.015"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2012.04463.x"},{"issue":"2","key":"e_1_2_11_20_1","first-page":"80","article-title":"Oxidative stress in patients with scalp seborrheic dermatitis","volume":"21","author":"Ozturk P","year":"2013","journal-title":"Acta Dermatovenerol Croat"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05303.x"},{"issue":"4","key":"e_1_2_11_22_1","first-page":"1089","article-title":"Evaluation of total antioxidant status, total oxidant status and oxidative stress index in patients with alopecia areata","volume":"7","author":"Motor S","year":"2014","journal-title":"Int J Clin Exp Med"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.3109\/15569527.2013.781616"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2010.00868.x"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.05.020"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2009.11.019"},{"issue":"6","key":"e_1_2_11_27_1","first-page":"367","article-title":"Association between Vitamin D levels and Alopecia Areata","volume":"16","author":"Mahamid M","year":"2014","journal-title":"Isr Med Assoc J"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.143567"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.3.327"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000018948.95175.03"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.13814","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.13814","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.13814","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T18:09:35Z","timestamp":1709316575000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.13814"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,11]]},"references-count":29,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1111\/jocd.13814"],"URL":"https:\/\/doi.org\/10.1111\/jocd.13814","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,11]]},"assertion":[{"value":"2020-09-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}