{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:07:21Z","timestamp":1775174841801,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T00:00:00Z","timestamp":1605139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Mechanisms involved in hair metabolism are diverse, and the availability of ingredients that normalize dysfunctions or mitigate the effects of extrinsic stress suffered daily is greatly desired by consumers to improve the aesthetic appearance of hair.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>In this work, we carried out a preclinical exploratory approach to evaluate the effects of a complex of nanoencapsulated active ingredients (AcPi), as well as a cosmetic formulation containing AcPi (ShPi and HtPi) in mechanisms involving hair loss and follicular aging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Human hair follicle dermal papilla cells and human scalp culture were treated with AcPi, ShPi, or HtPi and stimulated with UV radiation or testosterone for further measurement of mitochondrial biogenesis, reactive oxygen species (ROS), \u03b2\u2010catenin, dyhidrotestosterone (DHT), collagen XVII\u03b11 (COL17A1), and cutaneous permeation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our results demonstrated that AcPi prevents oxidative stress and balances mitochondial activity disturbed by exposure to UV radiation. AcPi also promoted an enrichment of <jats:italic>WNT<\/jats:italic>\/\u03b2\u2010catenin signaling pathway, stimulating hair growth, and lengthening the anagen phase\u00a0of hair cycle. ShPi and HtPi were able to prevent hair aging, minimizing the excessive degradation of COL17A1 in hair follicle exposed to UV radiation, in addition to controlling androgenic metabolism by reducing DHT production.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The integral effects of AcPi have not been completely elucidated; however, these results, associated with clinical evidences, allow us to infer that this ingredient prevents follicular aging, miniaturization, and consequently hair loss by mechanisms involving energetic homeostasis maintenance, antioxidant, and anti\u2010androgenic actions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13815","type":"journal-article","created":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T13:51:33Z","timestamp":1605189093000},"page":"2179-2189","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Novel complex of cosmetic ingredients with promising action in preventing hair loss and follicular aging through mechanism involving enrichment of <i>WNT<\/i>\/signaling, mitochondrial activity, and stem cells maintenance"],"prefix":"10.1111","volume":"20","author":[{"given":"Mamy","family":"Honda Igarashi","sequence":"first","affiliation":[{"name":"Hypera Pharma \u2013 Mantecorp Skincare Hynova Alphaville  S\u00e3o Paulo\u2010SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila Gomes","family":"da Silva","sequence":"additional","affiliation":[{"name":"Hypera Pharma \u2013 Mantecorp Skincare Hynova Alphaville  S\u00e3o Paulo\u2010SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Mercuri","sequence":"additional","affiliation":[{"name":"Hypera Pharma \u2013 Mantecorp Skincare Hynova Alphaville  S\u00e3o Paulo\u2010SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fl\u00e1via Macedo de Oliveira Neves","family":"Zuardi","sequence":"additional","affiliation":[{"name":"Hypera Pharma \u2013 Mantecorp Skincare Hynova Alphaville  S\u00e3o Paulo\u2010SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0111-7596","authenticated-orcid":false,"given":"Gustavo","family":"Facchini","sequence":"additional","affiliation":[{"name":"Kosmoscience Group Rua Sandoval Meirelles  Campinas\u2010SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo Henrique","family":"da Silva","sequence":"additional","affiliation":[{"name":"Kosmoscience Group Rua Sandoval Meirelles  Campinas\u2010SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Lucia Tabarini Alves Pinheiro","sequence":"additional","affiliation":[{"name":"Kosmoscience Group Rua Sandoval Meirelles  Campinas\u2010SP 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