{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T22:29:55Z","timestamp":1789079395563,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T00:00:00Z","timestamp":1604966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The use of the injectable products for soft tissue augmentation and treatment of skin aging is an uncomfortable, invasive and related to several complications, and chronic reactions, mainly after long\u2010term application. Efforts to develop new topically active anti\u2010aging products with fewer adverse effects are a huge challenge that should be faced.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>We evaluated the anti\u2010aging effects of a phytocosmetic preparation containing <jats:italic>Thymus vulgaris<\/jats:italic> associated with lecithin (ThymLec) on the facial wrinkles, expression lines, and face oval remodeling using a double\u2010blind placebo\u2010controlled clinical trial and in vitro cell culture assays.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A clinical trial was conducted to evaluate the effects of ThymLec 2% on the area, length, and depth of the perioral and crow's feet wrinkles, nasolabial and smile lines, as well as face oval remodeling in female volunteers using a sophisticated Bio3D Structured\u2010light Scanner. In the in vitro studies using 3T3\u2010L1 mouse embryonic fibroblasts, adiponectin was measured by immunoenzymatic assay, adipogenesis by the AdipoRed reagent method, and the PPAR\u2010\u03b3 expression by RT\u2010PCR analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Topical treatment with ThymLec 2% reduced facial wrinkles and expression lines promoting a face oval remodeling. In the in vitro studies, ThymLec upregulated the PPAR\u2010\u03b3 expression increasing adiponectin production and stimulating the adipogenesis process.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The phytocosmetic preparation containing <jats:italic>Thymus vulgaris<\/jats:italic> and lecithin is an innovative and safe topical anti\u2010aging product promoting fat tissue augmentation by adipogenesis stimulation <jats:italic>via<\/jats:italic> the upregulation of PPAR\u2010\u03b3 expression and adiponectin production.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13818","type":"journal-article","created":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T15:56:08Z","timestamp":1605023768000},"page":"2190-2202","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["A new phytocosmetic preparation from <i>Thymus vulgaris<\/i> stimulates adipogenesis and controls skin aging process: In vitro 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Department of Biophysics and Pharmacology Institute of Biosciences S\u00e3o Paulo State University (Unesp) Botucatu Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.15171\/apb.2019.042"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2011.07.020"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2165.2007.00289.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/geront\/gnw003"},{"key":"e_1_2_10_6_1","first-page":"309","article-title":"Skin anti\u2010aging strategies","volume":"4","author":"Ganceviene 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