{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:33:08Z","timestamp":1747186388514,"version":"3.40.5"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T00:00:00Z","timestamp":1606262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Breakages of the cold chain of botulinum neurotoxin A (BONT\u2010A) preparations is not a rare event and occurs due to several unexpected and unintentional reasons during daily practice and intervention schedules could not be proposed due to the lack of data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the heat stability of abobotulinum toxin A (AboBONT\u2010A) in terms of efficacy and duration of action upon storage at room temperature (25\u00b0C) for 2, 4, and 8\u00a0weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Materials<\/jats:title><jats:p>Twenty rabbits were divided into four groups and received an injection of ideally stored AboBONT\u2010A (Group 1) and stored AboBONT\u2010A for 2 (Group 2), 4 (Group 3), and 8\u00a0weeks (Group 4) at room temperature into the anterior auricular muscle. All rabbits were followed up and photographed by weekly for 16\u00a0weeks. Grade of paralysis was evaluated by using a modified visual scoring system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant alteration was found in initial potency of stored AboBONT\u2010A at room temperature for up to 4\u00a0weeks. Storage at room temperature for 2\u00a0weeks did not affect the duration of action (group 2; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.69), and faster recovery was observed in group 3 and group 4.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The bioactivity of AboBONT\u2010A is not altered till 2\u00a0weeks upon storage at room temperature.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13836","type":"journal-article","created":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T22:52:04Z","timestamp":1605048724000},"page":"1367-1373","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bioactivity of abobotulinum toxin is preserved till 2\u00a0weeks upon storage at room temperature: Half body comparative study on rabbit 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