{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T05:25:31Z","timestamp":1784179531780,"version":"3.55.0"},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T00:00:00Z","timestamp":1607040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Melasma is a common hyperpigmentation disorder with numerous, but often unsatisfactory treatment options.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>A pilot study to evaluate the efficacy and safety of a novel topical combination of 12% hydroquinone, 6% kojic acid, and 5% vitamin C cream for melasma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>A pilot study of 6 women with melasma was conducted at an academic dermatology department and a private dermatology practice to evaluate the efficacy of a topical combination of 12% hydroquinone, 6% kojic acid, and 5% vitamin C cream, entitled the \u201cTam Formula.\u201d Two blinded evaluators calculated Melasma Area and Severity Index (MASI) Scores before and after treatment to evaluate change from baseline, and statistical analysis was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Treatment with this combination topical cream resulted in an average 63.77\u00a0\u00b1\u00a022.10 percent reduction in MASI scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>While there is a need for further investigation, this pilot study indicates the Tam Formula may provide an alternative treatment option for melasma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13849","type":"journal-article","created":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T22:25:09Z","timestamp":1605738309000},"page":"2168-2171","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Tam formula: A pilot study for a new treatment for melasma"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3261-5985","authenticated-orcid":false,"given":"Radhika","family":"Srivastava","sequence":"first","affiliation":[{"name":"Department of Dermatology Rutgers Robert Wood Johnson Medical School at 1 World's Fair Drive Somerset  NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann M.","family":"John","sequence":"additional","affiliation":[{"name":"Department of Dermatology Rutgers Robert Wood Johnson Medical School at 1 World's Fair Drive Somerset  NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Tam","sequence":"additional","affiliation":[{"name":"Plastic Surgery Vegas  Las Vegas Nevada USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahar F.","family":"Firoz","sequence":"additional","affiliation":[{"name":"Department of Dermatology Rutgers Robert Wood Johnson Medical School at 1 World's Fair Drive Somerset  NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/120347540400800204"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12404"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.57602"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-013-0038-4"},{"key":"e_1_2_8_6_1","unstructured":"MillerNS.Prevent pigment problems in skin of color. 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