{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T09:48:08Z","timestamp":1774691288898,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T00:00:00Z","timestamp":1606953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Vitiligo is a common pigmentary skin disorder, and genetic factors were acknowledged to be greatly associated with the pathogenesis of this disease. Recently, increasing studies investigated the associations of methylenetetrahydrofolate reductase (<jats:italic>MTHFR<\/jats:italic>) rs1801131 and rs1801133 polymorphisms with risks of vitiligo, but the results still remained controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The current meta\u2010analysis was conducted to further evaluate the association of<jats:italic>MTHFR<\/jats:italic>polymorphisms with risk of vitiligo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eligible studies were searched in PubMed, EMBASE, Cochrane library, Chinese National Knowledge Infrastructure (CNKI), Technology of Chongqing (VIP), and Wan Fang Database until October 2020. All analyses were carried out using the Review Manager 5.3 software.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 6 studies that involved<jats:italic>MTHFR<\/jats:italic>rs1801131 and\/or rs1801133 polymorphism were finally included, which enrolled 3599 participants. Our results showed that no correlations were found between<jats:italic>MTHFR<\/jats:italic>rs1801131, rs1801133 polymorphisms and vitiligo risks in overall group. However, subgroup analysis revealed that rs1801131 polymorphism was significantly associated with increased vitiligo risk in the allelic (C vs A: OR\u00a0=\u00a01.15, 95% CI\u00a0=\u00a01.02\u20101.29,<jats:italic>P<\/jats:italic>\u00a0=\u00a0.02) and homozygous models (CC vs AA: OR\u00a0=\u00a01.48, 95% CI\u00a0=\u00a01.10\u20102.01,<jats:italic>P<\/jats:italic>\u00a0=\u00a0.01) in Asian population and that the rs1801133 polymorphism was significantly associated with decreased vitiligo risk in the allelic model (T vs C: OR\u00a0=\u00a00.82, 95% CI\u00a0=\u00a00.74\u20100.92,<jats:italic>P<\/jats:italic>\u00a0=\u00a0.0005) also in Asian population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This meta\u2010analysis confirmed the associations of<jats:italic>MTHFR<\/jats:italic>rs1801131 and rs1801133 polymorphisms with vitiligo risks and provided comprehensive insight into the pathogenesis of vitiligo.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13857","type":"journal-article","created":{"date-parts":[[2020,11,21]],"date-time":"2020-11-21T08:42:50Z","timestamp":1605948170000},"page":"2359-2368","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Associations of methylenetetrahydrofolate reductase gene (<i>MTHFR<\/i>) rs1801131 and rs1801133 polymorphisms with susceptibility to vitiligo: A meta\u2010analysis"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7704-2220","authenticated-orcid":false,"given":"Hua\u2010Zhu","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Pharmacy and Chemistry Dali University Dali China"},{"name":"Department of Pharmacy 920th Hospital of Joint Logistics Support Force Kunming 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