{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T08:38:25Z","timestamp":1779093505585,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,12,11]],"date-time":"2020-12-11T00:00:00Z","timestamp":1607644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hypertrophic scars (HS) are common pathologic processes emerged during wound\u2010healing process. The receptor\u2010interacting protein kinase (RIP) might participate in keloid formation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This study aimed to investigate Necrostatin\u20101 (Nec\u20101), a RIP1\/RIP3 inhibitor, in the formation of hypertrophic scar.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Human hypertrophic scar fibroblasts (HSF) were extracted from patients with hypertrophic scar. Transforming growth factor\u2010\u03b21 (TGF\u2010\u03b21) was performed to induce wound\u2010healing process including cell proliferation (CCK\u20108, Flow cytometry, and Western blot), migration (Transwell assay, Western blot), collagen production (Western blot), and extracellular matrix dysfunction (Western blotting and immunofluorescence).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our results reported that Nec\u20101 inhibited TGF\u2010\u03b21\u2010induced cell proliferation and promoted G0\/G1 phase arrest in HSF. In addition, Nec\u20101 attenuated TGF\u2010\u03b21\u2010induced cell migration and inhibited the expression of MMP2 and MMP9 in TGF\u2010\u03b21\u2010induced HSF. Besides, Nec\u20101 also reduced TGF\u2010\u03b21\u2010induced collagen production and \u03b1\u2010smooth muscle actin expression in HSF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present data in this study showed the potential role of Nec\u20101 as a novel treatment for HS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13860","type":"journal-article","created":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T15:58:12Z","timestamp":1606319892000},"page":"2612-2618","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Necrostatin\u20101, RIP1\/RIP3 inhibitor, relieves transforming growth factor \u03b2\u2010induced wound\u2010healing process in formation of hypertrophic scars"],"prefix":"10.1111","volume":"20","author":[{"given":"Pei\u2010Ting","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery Gansu Provincial Hospital  Lanzhou 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