{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T19:23:50Z","timestamp":1789759430455,"version":"4.0.1"},"reference-count":19,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T00:00:00Z","timestamp":1608595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Toxic epidermal necrolysis (TEN) (also known as Lyell syndrome) and Stevens\u2010Johnson syndrome (SJS) are life\u2010threatening mucocutaneous blistering diseases. They are characterized by generalized blisters and epidermal inflammation, most likely resulting from the administration or interaction of medicines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To report potential new method in the treatment of TEN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>This article presents a case report of a 35\u2010year\u2010old man suffering from TEN covering about 95% of his body surface. Lesions occurred in the patient during antiepileptic therapy, after taking simultaneously amoxicillin (with clavulanic acid) and naproxen followed by lamotrigine treatment. Standard general treatment was performed. Intravenous feeding was necessary. Due to acute respiratory failure, the patient required mechanical ventilation. Two methods were combined in topical treatment: application of platelet\u2010rich plasma (PRP) and a simultaneous biostatic human amnion transplant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the presented case, the combination of both methods contributed to a significant acceleration of wound healing. After the application of PRP and biostatic amnion transplantation, the healing of wounds on the back and posterior surfaces of the legs was completed after six days. The surgical treatment most probably contributed to a significant acceleration of wound healing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The case report shows that topical TEN\/SJS treatment with biostatic human amnion and PRP has a positive clinical effect and may be a new method of treatment of TEN.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13864","type":"journal-article","created":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T05:26:29Z","timestamp":1606281989000},"page":"2887-2893","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The use of biostatic human amnion and platelet\u2010rich plasma in topical treatment of toxic epidermal necrolysis\u2014A case report"],"prefix":"10.1111","volume":"20","author":[{"given":"Agnieszka","family":"Klama\u2010Bary\u0142a","sequence":"first","affiliation":[{"name":"Stanislaw Sakiel Burn Treatment Centre in Siemianowice Slaskie 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