{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T16:09:44Z","timestamp":1760890184064,"version":"3.40.5"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,21]],"date-time":"2020-12-21T00:00:00Z","timestamp":1608508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>UV\u2010induced oxidative skin stress leads to cutaneous photoaging. The objective of these 2 studies was to evaluate a nature\u2010based botanical facial oil for the ability to decrease UV\u2010induced oxidative skin stress.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>22 females were enrolled in the UVA study, and 10 females were enrolled in the UVB study. Skin chemiluminescence induced by UVA exposure was measured at baseline and after 2\u00a0weeks of daily topical application of the nature\u2010based facial oil was evaluated in study 1. In study 2, UVB\u2010induced erythema was measured after 8\u00a0weeks of twice\u2010daily topical application of the nature\u2010based facial oil to a photoprotected site followed by skin biopsy to evaluate sunburn cell formation. In both studies, the treatment response was compared to the response on untreated skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The nature\u2010based facial oil significantly reduced skin chemiluminescence following UVA exposure, demonstrating antioxidant activity. The nature\u2010based facial oil also significantly reduced erythema formation following UVB exposure and resulted in reduced sunburn cell formation in 66.67% of subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Topical nature\u2010based facial oil can reduce UV\u2010induced oxidative cutaneous damage.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13879","type":"journal-article","created":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T18:35:05Z","timestamp":1608662105000},"page":"522-525","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Nature\u2010based botanical facial oil oxidative stress protection"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9803-7415","authenticated-orcid":false,"given":"Zoe","family":"Diana Draelos","sequence":"first","affiliation":[{"name":"Dermatology Consulting Services  PLLC High Point NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hemali","family":"Gunt","sequence":"additional","affiliation":[{"name":"Burt's Bees  Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanley B.","family":"Levy","sequence":"additional","affiliation":[{"name":"Chapel Hill Dermatology  Chapel Hill NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,21]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"United States Environmental Protection Agency.Health effects of UV radiation. 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