{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T13:54:36Z","timestamp":1752674076218,"version":"3.40.5"},"reference-count":15,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,12,21]],"date-time":"2020-12-21T00:00:00Z","timestamp":1608508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Treatment of unwanted body hair is a challenging area in cosmetic dermatology. Topical soy isoflavones and derivatives or eflornithine have been utilized in dermatocosmetology for their estrogenic and antiandrogenic activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate the efficacy of a formulation containing capryloyl glycine 4% in decreasing hair growth on the forearms after topical application for 120\u00a0days vs placebo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 69 female patients entered the study (age 37\u00a0\u00b1\u00a06). Hair growth was quantified using TrichoScan software on both forearms at 20\u2010fold magnification (analyzed area 0.651 cm2). Hair density (number of hairs\/cm<jats:sup>2<\/jats:sup>), density vellus hair, density terminal hair, and median length of hairs were evaluated. The data were analyzed using ANOVA for repeated measures to evaluate changes during the treatment (T0, T60, and T120) and Student's <jats:italic>t<\/jats:italic> test (placebo vs active).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a significant decrease on hair density, median, and terminal hair at the end of the treatment in the active\u2010treated site (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) as measured by TrichoScan software. Direct comparison between active and placebo\u2010treated sites showed no significant differences at T0, but highly significant differences at T120 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The study shows that a cosmetic formulation based on capryloyl glycine 4% is highly effective in reducing several parameters related to hair growth and hair thickness vs placebo, thus showing efficacy in the treatment of hypertrichosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13893","type":"journal-article","created":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T13:24:27Z","timestamp":1608643467000},"page":"2527-2530","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Assessment of the skin efficacy and acceptability of a cosmetic product in the treatment of the forearm hypertrichosis in female patients"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3423-5038","authenticated-orcid":false,"given":"Enzo","family":"Berardesca","sequence":"first","affiliation":[{"name":"Phillip Frost Department of Dermatology University of Miami Miami FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6535-6935","authenticated-orcid":false,"given":"Norma","family":"Cameli","sequence":"additional","affiliation":[{"name":"San Gallicano Dermatological Institute Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Piacentini","sequence":"additional","affiliation":[{"name":"Eurofins Cosmetics &amp; Personal Care Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Veraldi","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Transplantation Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo","family":"Celleno","sequence":"additional","affiliation":[{"name":"Department of Dermatology Catholic University of Rome Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(64)92789-8"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.1999.08130.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(85)70062-X"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2165.2008.00363.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-2126(99)80073-2"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/360355a0"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200102030-00009"},{"issue":"7","key":"e_1_2_9_9_1","first-page":"930","article-title":"Combination of intense pulse light and topical eflornithine therapy versus intense pulse light therapy alone in the treatment of idiopathic facial hirsutism: a randomized controlled trial","volume":"69","author":"Zahoor H","year":"2019","journal-title":"J Pak Med Assoc"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/14764172.2012.699680"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.12.019"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2016.12.007"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0625.2001.100603.x"},{"key":"e_1_2_9_14_1","first-page":"280","article-title":"Clinical inquiries. 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