{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T17:32:19Z","timestamp":1770139939974,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T00:00:00Z","timestamp":1608595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Allergic contact dermatitis to cosmetics (ACDC) complicates the diagnosis and treatment of rosacea, and is increasingly observed in daily practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The present study aimed to identify the contact allergens responsible for ACDC in Chinese female rosacea patients with or without suspected ACDC (SACDC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From a total of 1267 women with rosacea, 122 with SACDC, 145 without SACDC, and 100 age\u2010matched healthy controls without rosacea or SACDC were examined on a voluntary basis. Skin patch tests with C\u20101000 cosmetic series (Chemotechnique Diagnostics, Malmo, Sweden) were conducted, including 20 selected allergens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Positive allergic reaction was found in 85.2% and 33.8% of SACDC and non\u2010SACDC (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), respectively, and 27.0% of healthy volunteers. Most reactions occurred at day 3, and the majority of all the examinees including normal controls reacted to more than 1 allergen. In SACDC patients, leading allergens were methylchloroisothiazolinone\/methylisothiazolinone (28.7%), linalool hydroperoxide (27.1%), fragrance mix I (21.3%), methylisothiazolinone (17.2%), limonene hydroperoxides (16.4%), formaldehyde (14.8%), myroxylon pereirae (13.9%), and propolis (10.7%); the overall allergic reaction rate positively correlated with new onset of facial pruritus (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). The occurrence of irritant contact reactions correlated with positive allergic reactions in rosacea patients with or without SACDC (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.032 or <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Preservatives and fragrances are primary culprits for ACDC in Chinese female rosacea patients. Patch testing should be considered in the suspected patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13902","type":"journal-article","created":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T00:57:43Z","timestamp":1608685063000},"page":"2627-2634","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Contact sensitization to cosmetic series of allergens in female patients with rosacea: A prospective controlled study in China"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6540-8726","authenticated-orcid":false,"given":"Bangtao","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Dermatology the Third Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fubing","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Dermatology the Third Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WenChieh","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Technical University of Munich Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengqiu","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Dermatology the Third Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Dermatology the Third Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daojun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology the Third Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Dermatology the Third Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2013.09.006"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12078"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01073.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14822"},{"key":"e_1_2_8_6_1","first-page":"1","article-title":"Patch test in Chinese in Shanghai with cosmetic allergy to cosmetic series and products","volume":"19","author":"Qin O","year":"2019","journal-title":"J Cosmet 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