{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T17:35:11Z","timestamp":1785432911298,"version":"3.56.0"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T00:00:00Z","timestamp":1608681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Vitiligo is a common acquired disorder of depigmentation. Its pathogenesis entails a T helper (Th) 1\u2010cytotoxic T (cT) lymphocytes mediated autoimmune melanocyte destruction. Interleukin (IL)\u201015 is one of the IL\u20102 family of cytokines and shares several actions with IL\u20102. IL\u201015 enhances survival, maturation, and functional activity of natural killer, neutrophils, and dendritic cells. Furthermore, it potentiates survival, maturation, and cytotoxicity of memory cT cells. IL\u201015 has been shown to play a crucial role in the pathogenesis of several autoimmune diseases but was poorly investigated in patients with vitiligo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The study aimed at evaluating IL\u201015 level in the sera of patients with vitiligo and its association with vitiligo severity and activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>The study included 30 patients with nonsegmental vitiligo and 30 healthy controls. Vitiligo Extent Score (VES) and Vitiligo Disease Activity (VIDA) score were used to assess vitiligo severity and activity, respectively. Serum level of IL\u201015 was assessed by enzyme\u2010linked immune\u2010sorbent assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum IL\u201015 level, in patients with vitiligo, was significantly higher in comparison with the control group (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.001). A significant positive correlation was found between serum IL\u201015 level and VES score (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.001), whereas there was no significant correlation between IL\u201015 level and VIDA score as well as the disease duration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>IL\u201015 level was elevated in the sera of patients with vitiligo. IL\u201015 may therefore have a significant impact on vitiligo autoimmune pathogenesis, and further identification of its molecular roles may highlight new therapeutic strategies for vitiligo.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13908","type":"journal-article","created":{"date-parts":[[2020,12,24]],"date-time":"2020-12-24T14:35:25Z","timestamp":1608820525000},"page":"2640-2644","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Elevated serum level of interleukin\u201015 in vitiligo patients and its correlation with disease severity but not activity"],"prefix":"10.1111","volume":"20","author":[{"given":"Mona A.","family":"Atwa","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology Faculty of Medicine Suez Canal University Ismailia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara Mohammed Mohammed","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ministry of Health and Population El Arish General Hospital North Sinai Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahed","family":"Youssef","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology Faculty of Medicine Suez Canal University Ismailia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8144-0926","authenticated-orcid":false,"given":"Radwa El\u2010Sayed","family":"Mahmoud Marie","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology Faculty of Medicine Suez Canal University Ismailia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v3.i3.221"},{"key":"e_1_2_11_3_1","article-title":"Genetic polymorphism of liver X receptor gene in vitiligo: does it have an association?","author":"Shehata WA","year":"2020","journal-title":"J Cosmet Dermatol"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2010.09.003"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2009.09.009"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.1.14"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-05-156307"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/943156"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2005.10.003"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.4.2240"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijt.ijt_80_18"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200318986"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700046"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2015.12.040"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13311"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.135.4.407"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.181.3.1255"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0801792"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.08.038"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aam7710"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3962"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2019.05.011"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700896"},{"issue":"7","key":"e_1_2_11_24_1","article-title":"IL\u201015 and IL\u201023 synergize to trigger Th17 response by CLA+ T cells in psoriasis","volume":"29","author":"Jes\u00fas\u2010Gil C","year":"2020","journal-title":"Exp Dermatol"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.11.034"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1159\/000508515"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.13908","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.13908","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.13908","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T19:45:29Z","timestamp":1693338329000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.13908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,23]]},"references-count":25,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1111\/jocd.13908"],"URL":"https:\/\/doi.org\/10.1111\/jocd.13908","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,23]]},"assertion":[{"value":"2020-11-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}