{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:33:18Z","timestamp":1747186398941,"version":"3.40.5"},"reference-count":12,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,1,9]],"date-time":"2021-01-09T00:00:00Z","timestamp":1610150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Lichen planus is a common chronic cutaneous inflammatory disease. Recent advances evidenced that angiogenesis is tightly connected to it. More recently, the endothelial specific growth factor angiopoietin\u20102 has been clarified to interact with vascular endothelial growth factor. Angiopoietin\u20102 level has not been investigated in lichen planus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate serum level of angiopoietin\u20102 in cutaneous and oral lichen planus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ninety patients were investigated, 45 patients with lichen planus. In addition to forty\u2010five healthy control, the activity of the disease was estimated at the time of examination. The serum level of angiopoietin\u20102 had been estimated by enzyme\u2010linked immunosorbent assay. The relationships between angiopoietin\u20102 serum level and disease severity, type of lichen, and visual analogue scale score (VAS) were determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The serum levels of angiopoietin\u20102 were substantially higher in patients with both cutaneous and oral lesions than patients with cutaneous lichen planus only (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Serum angiopoietin\u20102 is elevated in patients compared with normal subjects and is correlated with the presence of oral lesions and disease severity, that reflects its role in angiogenesis and inflammation, and angiopoietin\u20102 serum level could be a potential marker for monitoring the oral lichen to identify possible malignant transformation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13926","type":"journal-article","created":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T18:55:52Z","timestamp":1609786552000},"page":"2940-2944","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Serum angiopoietin\u20102 level as a novel potential biomarker in oral lichen planus"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2960-8445","authenticated-orcid":false,"given":"Hagar","family":"Bessar","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology Faculty of Medicine Zagazig University Zagazig Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noha M.","family":"Hammad","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology Department Faculty of Medicine Zagazig University Zagazig Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tawhed","family":"Ismail","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology Faculty of Medicine Zagazig University Zagazig Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed AbdElkader","family":"Teama","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology Faculty of Medicine Zagazig University Zagazig Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayman","family":"Youssef","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology Faculty of Medicine Zagazig University Zagazig Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,9]]},"reference":[{"issue":"6","key":"e_1_2_9_2_1","first-page":"697","article-title":"Quantitative immunohistochemical assessment of blood and lymphatic microcirculation in cutaneous lichen planus lesions","volume":"30","author":"V\u00fdbohov\u00e1 D","year":"2014","journal-title":"Histol 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