{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T01:26:56Z","timestamp":1791509216048,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T00:00:00Z","timestamp":1611014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>We aimed to reveal the relationship of serum uric acid (SUA) with monocyte\u2010high\u2010density lipoprotein ratio (MHR) and other inflammatory markers in acne patients before and after isotretinoin treatment. In this way, we can try to shed light on the relationship between isotretinoin treatment and atherosclerosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two hundred twenty\u2010four acne patients who administered isotretinoin (0.5\u20101\u00a0mg\/kg\/day) were enrolled in the study. In the pretreatment phase and 3\u00a0months after treatment, MHR, SUA, mean platelet volume, neutrophil\u2010lymphocyte ratio (NLR), platelet\u2010lymphocyte ratio, monocyte\u2010lymphocyte ratio, serum triglyceride, total cholesterol, high\u2010density lipoprotein (HDL), and low\u2010density lipoprotein (LDL) levels of the patients were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to the pretreatment phase, three months after treatment, there was a statistically decrease in neutrophil count and an increase in lymphocyte count (p: 0.002, p: 0.011, respectively). Accordingly, there was a statistically significant decrease in NLR (p: 0.001). It was noteworthy that MHR and SUA levels increased significantly (p: 0.042, p: 0.010, respectively) and there was a positive correlation between SUA level and MHR (r: 0.212, p: 0.012). Serum total cholesterol, LDL, and triglyceride levels increased and HDL levels decreased significantly after treatment (p: 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study contributes to the comprehension of the relationship between isotretinoin treatment and atherosclerosis, which has been frequently reported in the literature. It was thought that the isotretinoin\u2010induced SUA increase might be related to dyslipidemia. Isotretinoin may initiate the atherosclerotic process in vascular endothelial and smooth muscles, with SUA increase and HDL decrease. An increase in MHR is also an inflammatory marker indicating this process.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13931","type":"journal-article","created":{"date-parts":[[2021,1,2]],"date-time":"2021-01-02T13:43:40Z","timestamp":1609595020000},"page":"2945-2949","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Increases in uric acid and monocyte\u2010high\u2010density lipoprotein ratio as possible atherosclerotic indicators in acne patients using isotretinoin"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1251-6333","authenticated-orcid":false,"given":"Nurcan","family":"Metin","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology The Republic of Turkey, Health Sciences University Erzurum City Hospital Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6111-4314","authenticated-orcid":false,"given":"\u00c7a\u011fr\u0131","family":"Turan","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology The Republic of Turkey, Health Sciences University Erzurum City Hospital Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1702493"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12483"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13254"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.5455\/medscience.2013.02.8101"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2019.104267"},{"issue":"3","key":"e_1_2_7_7_1","first-page":"101","article-title":"What do 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