{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T23:46:53Z","timestamp":1784677613312,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,1,16]],"date-time":"2021-01-16T00:00:00Z","timestamp":1610755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A new topical formulation (TF) based on 3 main lifting components has been developed to reduce superficial facial wrinkles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Determine the effectiveness of this new TF in reducing superficial face wrinkles and restructuring the dermal matrix.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Women, aged 30\u201065\u00a0y.o. with moderate to severe crow's feet wrinkles were included. Exclusion criteria: men; younger than 30 or older than 65\u00a0years old; smokers. Patients received 15\u00a0IU of botulinum toxin on crow's feet and 2 creams. Fifty patients (Group 1) applied the TP (Product A) and 50 (Group 2) a placebo (Product B). Assessments were made by digital macro\u2010photography's, Antera 3D, and a patient satisfaction questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From April to June 2019, 100 women were enrolled in the study and were divided into two homogeneous groups. No major or minor side effects were reported. In group 1, wrinkles, texture, static and dynamic crow's feet wrinkles improved significantly at 3 and 6\u00a0months. Patients were very satisfied at 3\u00a0months and satisfied at 6\u00a0months. In group 2, wrinkles and texture improved significantly at 3\u00a0months but did not improve at 6\u00a0months. Static and dynamic crow's feet wrinkles improved significantly at 1 and 3\u00a0months but did not improve significantly at 6\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our prospective and randomized study has shown that the new TF is safe and effective in reducing superficial face wrinkles and producing dermal regeneration. It, therefore, prolongs the duration of the botulinum toxin. Further controlled study would be necessary to compare the new TF to neurotoxin treatment, or its action alone.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13937","type":"journal-article","created":{"date-parts":[[2021,1,16]],"date-time":"2021-01-16T13:36:56Z","timestamp":1610804216000},"page":"2832-2840","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Prospective randomized clinical study of a new topical formulation for face wrinkle reduction and dermal regeneration"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4177-9976","authenticated-orcid":false,"given":"Antonino","family":"Araco","sequence":"first","affiliation":[{"name":"Aesthetic Medicine Department Cosmetic Surgeon at Univeristy Tor Vergata of Roma Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Araco","family":"Francesco","sequence":"additional","affiliation":[{"name":"Aesthetic Doctor Private Practice in Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1975.tb05113.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.199579"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1992.tb16986.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1962.122"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(08)80964-4"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12524421"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjw074"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2007.06.015"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12318471"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom5020545"},{"key":"e_1_2_8_12_1","first-page":"67","article-title":"Muscolar aging and its involvement in facial aging: the face recurve concept","volume":"136","author":"Louarn C","year":"2009","journal-title":"Ann Dermatol Venereol"},{"key":"e_1_2_8_13_1","first-page":"1262","article-title":"\u201cDeep heating\u201d noninvasive skin tightening devices: Review of effectiveness and patient satisfaction","volume":"16","author":"Chilukuri S","year":"2017","journal-title":"J Drug Dermatol"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000002851"},{"key":"e_1_2_8_15_1","first-page":"543","article-title":"Waglerin\u20101 selectively blocks the epsilon form of the muscle nicotinic acetylcholine receptor","volume":"289","author":"McArdle JJ","year":"1999","journal-title":"J Pharmacol Exp Therapy"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi025732d"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.3228405"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.80692"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1051\/jbio\/1999193040423"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.7555\/JBR.31.20150175"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12696"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12177"},{"key":"e_1_2_8_23_1","first-page":"268","article-title":"Quantitative evaluation of atrophic acne scars using 3D image analysis with reflected LED light Skin","volume":"2","author":"Tanizaki H","year":"2019","journal-title":"Res Technol"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.24204"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-13-3681-2_10"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001076"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003789"},{"key":"e_1_2_8_28_1","doi-asserted-by":"crossref","first-page":"851","DOI":"10.2147\/CCID.S227493","article-title":"Real\u2010world safety and effectiveness of onabotulinumtoxina treatment of crow's feet lines and glabellar lines: results of a korean postmarketing surveillance study","volume":"12","author":"Dong\u2010Jin SW","year":"2019","journal-title":"Investig Dermatol"},{"key":"e_1_2_8_29_1","first-page":"116","article-title":"Skin characterization and immediate effects of different dermocosmetic treatments in French and Brazilian skin","volume":"24","author":"Salom\u00e3o Calixto L","year":"2019","journal-title":"J Cosmet Dermatol"},{"key":"e_1_2_8_30_1","first-page":"716","article-title":"Combined treatment with platelet\u2010rich plasma and insulin favours chondrogenic and osteogenic differentiation of human adipose\u2010derived stem cells in three\u2010dimensional collagen scaffolds","volume":"33","author":"Scioli G","year":"2009","journal-title":"Aesthetic Plast Surg"},{"key":"e_1_2_8_31_1","first-page":"302","article-title":"Autologous platelet\u2010rich plasma mixed with purified fat graft in aesthetic plastic surgery","volume":"42","author":"Cervelli V","year":"2020","journal-title":"Int J Cosmet Sci"},{"key":"e_1_2_8_32_1","first-page":"191","article-title":"Comparing different nanofat procedures on scars: role of the stromal vascular fraction and its clinical implications","volume":"434","author":"Gentile P","year":"2013","journal-title":"Biomed Res Int"},{"key":"e_1_2_8_33_1","first-page":"431","article-title":"Our experience and current state of art in the combined use of fat and PRP","volume":"9","author":"Cervelli V","year":"2020","journal-title":"Int J Mol Sci"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.2498"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12617"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20143446"},{"key":"e_1_2_8_37_1","first-page":"851","article-title":"Comparative physicochemical stability and clinical anti\u2010wrinkle efficacy of transdermal emulgel preparations of 5% sodium ascorbyl phosphate and or ascorbic acid on human volunteers","volume":"12","author":"Mohammadi S","year":"2019","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"e_1_2_8_38_1","first-page":"845","article-title":"Dermocosmetic emulgels for anti\u2010aging effects: Evidence from chromatographic and non\u2010invasive biophysical techniques","volume":"32","author":"Kashif M","year":"2019","journal-title":"Pak J Pharm Sci"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12173"},{"key":"e_1_2_8_40_1","first-page":"471","article-title":"Facial primer provides immediate and long\u2010term improvements in mild\u2010to\u2010moderate facial hyperpigmentation and fine lines associated with photoaging","volume":"8","author":"Roberts WE","year":"2015","journal-title":"Clin Cosmet Investig Dermatol"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.13937","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.13937","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.13937","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T14:29:18Z","timestamp":1724336958000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.13937"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,16]]},"references-count":39,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1111\/jocd.13937"],"URL":"https:\/\/doi.org\/10.1111\/jocd.13937","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,16]]},"assertion":[{"value":"2020-05-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}