{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:35:17Z","timestamp":1788543317100,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,1,16]],"date-time":"2021-01-16T00:00:00Z","timestamp":1610755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Androgenetic alopecia (AGA) is the most common form of alopecia in men. Cetirizine, a second\u2010generation H1 blocker, is known for its anti\u2010inflammatory properties and its ability to decrease prostaglandin D2 (PGD2) production.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the efficacy and tolerability of topical cetirizine in male patients with AGA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Two groups of 30 patients each (healthy males aged between 22 and 55\u00a0years) with different grades of AGA classified according to the Hamilton\u2010Norwood classification were recruited for this study. Group A subjects applied 1\u00a0mL of 1% topical cetirizine daily, while group B subjects served as controls and were instructed to apply 1\u00a0mL of a placebo solution for 6\u00a0months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Dermoscopic assessment revealed significantly higher hair regrowth among the cetirizine\u2010treated group (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001). The patients\u2019 satisfaction was significantly higher among the cetirizine\u2010treated group (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The current study highlights a potential role cetirizine might have in treating AGA. It should be noted that studies are lacking in this regard and more randomized and controlled trials are warranted in order to confirm or refute such early findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.13940","type":"journal-article","created":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T15:53:39Z","timestamp":1610553219000},"page":"1154-1159","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Therapeutic implications of topical cetirizine 1% in treatment of male androgenetic alopecia: A case\u2010controlled study"],"prefix":"10.1111","volume":"20","author":[{"given":"Mohamed S.","family":"Zaky","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology Faculty of Medicine Al\u2010Azhar University Damietta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Abo Khodeir","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology Faculty of Medicine Al\u2010Azhar University Damietta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hebat\u2010Allah","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology Faculty of Medicine Al\u2010Azhar University Damietta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7541-5241","authenticated-orcid":false,"given":"Mohamed L.","family":"Elsaie","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology National Research Centre Cairo 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