{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T14:59:38Z","timestamp":1780498778074,"version":"3.54.1"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T00:00:00Z","timestamp":1612828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Skin darkening because of increased and irregular synthesis of melanin causes melasma, solar lentigo, and freckles. Melasolv\u2122, produced in the early 2000s, shows potent depigmenting effect and has low cytotoxicity. It has been used as a brightening agent in cosmetics for decades.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This study was conducted to investigate whether Melasolv\u2122 is effective for the skin of ASEAN (Southeast Asia) women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We recruited ASEAN women in Singapore and divided them into two groups (active group vs. placebo group). Melasolv<jats:sup>\u2122<\/jats:sup> and placebo formulations were applied twice a day for 12\u00a0weeks. The changes in the pigmented spots were visually evaluated by an expert and assessed using a spectrophotometer and Mexameter at 0, 4, 8, and 12\u00a0weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The visual evaluation revealed significant improvements, in both size and color intensity, in the active group compared with those in the placebo group at 12\u00a0weeks. In the spectrophotometric evaluation, the L* value of the pigmented spots in the active group was significantly higher than that in the placebo group at 12\u00a0weeks. Similar results were obtained in the evaluation using the Mexameter. After 12\u00a0weeks, the melanin index of the pigmented spots significantly decreased, and it was significantly higher than that in the placebo group. There was no significant change in the erythema index. In the image analysis, there were no significant differences in skin color brightness and evenness in the active group compared with those in the placebo group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Melasolv<jats:sup>\u2122<\/jats:sup> can be effective used for skin brightening.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13969","type":"journal-article","created":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T00:01:54Z","timestamp":1612569714000},"page":"2851-2859","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Clinical brightening efficacy and safety of Melasolv\u2122 (3,4,5\u2010trimethoxy cinnamate thymol ester, TCTE) in Southeast Asian women"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3606-1644","authenticated-orcid":false,"given":"Seung Hun","family":"Kim","sequence":"first","affiliation":[{"name":"AMOREPACIFIC Research and Development Center Gyeonggi\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung Ryol","family":"Paik","sequence":"additional","affiliation":[{"name":"AMOREPACIFIC Research and Development Center Gyeonggi\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Hoon","family":"Lee","sequence":"additional","affiliation":[{"name":"AMOREPACIFIC Research and Development Center Gyeonggi\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So Mi","family":"Lee","sequence":"additional","affiliation":[{"name":"AMOREPACIFIC Research and Development Center Gyeonggi\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"AMOREPACIFIC Research and Development Center Gyeonggi\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Joo","family":"Kim","sequence":"additional","affiliation":[{"name":"AMOREPACIFIC Research and Development Center Gyeonggi\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin Yong","family":"Leow","sequence":"additional","affiliation":[{"name":"Institut d\u2019Expertise Clinique (IEC) Singapore Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9311-3191","authenticated-orcid":false,"given":"Changhui","family":"Cho","sequence":"additional","affiliation":[{"name":"Clinical Research Center Institut d\u2019Expertise Clinique (IEC) Korea Suwon\u2010si, Gyeonggi\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won\u2010Seok","family":"Park","sequence":"additional","affiliation":[{"name":"AMOREPACIFIC Research and Development Center Gyeonggi\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung\u2010Fhy","family":"Suh","sequence":"additional","affiliation":[{"name":"AMOREPACIFIC Research and Development Center Gyeonggi\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,9]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"135","article-title":"The inhibitory effects of 3,4,5\u2010Trimethoxycinnamate thymol ester (TCTE, Melasolv\u00ae) on melanogenesis","volume":"28","author":"Hwang JS","year":"2002","journal-title":"J Soc Cosmet Sci Korea"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.51.1085"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-014-1439-9"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2003.01621.x"},{"key":"e_1_2_9_6_1","first-page":"21","article-title":"Efficacy of Trifecting\u00ae Night Cream, a novel triple acting skin 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