{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:13:10Z","timestamp":1787015590932,"version":"build-2736575974"},"reference-count":18,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T00:00:00Z","timestamp":1613088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Pumpkin (\n Cucurbita pepo<\/jats:italic>\n L.) is an annual climber plant, and its seeds have considerable amount of oil with nutritional and medicinal importance.\n <\/jats:p>\n <\/jats:sec>\n \n Aim<\/jats:title>\n The present study aimed to investigate the clinical efficacy of pumpkin seed oil (PSO) in the treatment of female pattern hair loss (FPHL) and compare its effects with minoxidil 5% foam.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Patients with FPHL were randomly assigned to pumpkin seed oil (n\u00a0=\u00a030; group A) or minoxidil 5% foam (n\u00a0=\u00a030; group B) for a period of 3\u00a0months. Patients were evaluated clinically and dermoscopically at baseline, at one and half months, and at the end of the 3\u2010month study.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Among group A (pumpkin seed oil) candidates, a significant decrease was observed in hair shaft diversity before and after treatment (30.5\u00a0\u00b1\u00a06.2%, 24.0\u00a0\u00b1\u00a04.02,\n P<\/jats:italic>\n \u00a0<\u00a0.001, respectively) as well as in the vellus hairs (22.5\u00a0\u00b1\u00a04.9, 15.8\u00a0\u00b1\u00a02.2,\n P<\/jats:italic>\n \u00a0<\u00a0.001, respectively). Upright regrowing hairs significantly increased from (0.13\u00a0\u00b1\u00a00.5) before treatment to (0.9\u00a0\u00b1\u00a01.0) after treatment (\n P<\/jats:italic>\n \u00a0<\u00a0.001). In group B (minoxidil applying) candidates, a significant decrease was observed in hair shaft diversity before and after treatment (31.5\u00a0\u00b1\u00a06.3%, 21.3\u00a0\u00b1\u00a02.2,\n P<\/jats:italic>\n \u00a0<\u00a0.001, respectively) as well as in the vellus hairs (24.7\u00a0\u00b1\u00a06.4, 19.5\u00a0\u00b1\u00a05.4,\n P<\/jats:italic>\n \u00a0=\u00a0.02, respectively). Conclusion Findings of the present trial provide evidence of a promising potential role of PSO in treating FPHL.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jocd.13976","type":"journal-article","created":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T13:14:24Z","timestamp":1612530864000},"page":"2867-2873","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Pumpkin seed oil vs. minoxidil 5% topical foam for the treatment of female pattern hair loss: A randomized comparative trial"],"prefix":"10.1111","volume":"20","author":[{"given":"Ibrahim M.","family":"Ibrahim","sequence":"first","affiliation":[{"name":"Department of Dermatology Al\u2010Azhar University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed S.","family":"Hasan","sequence":"additional","affiliation":[{"name":"Department of Dermatology Al\u2010Azhar University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled I.","family":"Elsabaa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Al\u2010Azhar University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7541-5241","authenticated-orcid":false,"given":"Mohamed L.","family":"Elsaie","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Research Centre Cairo 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KE","year":"2019","journal-title":"Am J Dermatol Venereol"},{"issue":"6","key":"e_1_2_7_18_1","first-page":"499","article-title":"Beneficial effects of pumpkin seed oil as a topical hair growth promoting agent in a mice model","volume":"9","author":"Hajhashemi V","year":"2019","journal-title":"Avicenna J Phytomed"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.4162\/nrp.2009.3.4.323"}],"container-title":["Journal of Cosmetic 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