{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T21:34:34Z","timestamp":1790026474030,"version":"4.0.1"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T00:00:00Z","timestamp":1613347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Topical anesthesia is widely used in many dermatological and cosmetic procedures. Nevertheless, the stratum corneum serves as the skin barrier, impedes the transdermal drug delivery greatly, and results in insufficient analgesia. Cold atmospheric plasma (CAP) has been researched as a transdermal drug delivery promoter with ex vivo experiments for a few years, while clinical trials are scarce.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To assess the efficacy and safety of CAP as a pretreatment to improve the transdermal absorption of topical anesthetic cream before the CO<jats:sub>2<\/jats:sub> laser treatment for postacne scars in the human body.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>Twenty patients, seeking full facial laser treatment for atrophic acne scars, underwent a randomized split\u2010face study. One side of the face was pretreated by CAP before topical anesthetic cream was applied, and the other side was applied with topical anesthetic cream only as control. After that, the subjects went through full\u2010face fractional CO<jats:sub>2<\/jats:sub> laser treatment of postacne scars. They were asked to score the pain on a visual analogue scale (VAS) after the laser treatment to measure the anesthesia effects which indicates the transdermal absorption of the cream. Possible adverse effects of the plasma were recorded during the pretreatment including associated pain, heat, erythema, and edema.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The VAS score of the treated side was statistically lower (5.1\u00a0\u00b1\u00a02.1) compared with the nontreated side (6.3\u00a0\u00b1\u00a01.9), with a mean difference of 1.3 (95% confidence interval [CI], 0.6\u20101.9; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001). No severe adverse event was reported, and all the disturbing sensations and symptoms (pain, heat, and edema) were evaluated as mild with no mean score surpassing 4.0.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Plasma pretreatment of 5\u00a0minutes before topical anesthetic cream application gives significant pain reduction during the laser procedures, showing the potential effects of CAP on promoting transdermal drug delivery, with no obvious adverse effects reported.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13983","type":"journal-article","created":{"date-parts":[[2021,2,7]],"date-time":"2021-02-07T02:49:43Z","timestamp":1612666183000},"page":"2794-2799","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Analgesic effect of topical lidocaine is enhanced by cold atmospheric plasma pretreatment in facial CO<sub>2<\/sub> laser treatments"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9205-1029","authenticated-orcid":false,"given":"Yue","family":"Xin","sequence":"first","affiliation":[{"name":"Department of Dermatovenereology West China Hospital Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0512-6502","authenticated-orcid":false,"given":"Xiang","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Dermatovenereology West China Hospital Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Dermatovenereology West China Hospital Sichuan University Chengdu China"},{"name":"Laboratory of Dermatology Clinical Institute of Inflammation and Immunology (CIII) Frontiers Science Center for Disease\u2010Related Molecular Network West China Hospital 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