{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:33:26Z","timestamp":1747186406699,"version":"3.40.5"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T00:00:00Z","timestamp":1614643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Beauty is closely associated with a sense of calm, confidence, and hope for a better life. Therefore, it is expected that improving the appearance or even correcting one's view of appearance can prevent depression and even improve different degrees of depression in individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>Investigation of whether using botulinum injections (a common method of improving facial esthetics) can improve the degree of depression in clients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective interventional before\u2010after study was conducted on 121 consecutive individuals referred for beautifying the face. Before performing the interventional procedure by facial botulinum injection as well as one month later, the depression status was examined by the Beck Depression Inventory II (BDI) questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean baseline depression score dropped from 18.9\u00a0\u00b1\u00a04.8 to 10.6\u00a0\u00b1\u00a02.9 during the follow\u2010up time (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). Using the multivariable linear regression modeling and with the presence of baseline parameters, the main determinants of improving depression score included young ages (beta = \u22120.541, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.001), higher educational level (beta\u00a0=\u00a00.595, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.015), and previous experiences of botulinum toxin use (beta\u00a0=\u00a01.072, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.036).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The improvement in people's moods along with correction of their facial defects following botulinum toxin injections would be expected.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13990","type":"journal-article","created":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T09:19:55Z","timestamp":1612948795000},"page":"1411-1415","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The healing effects of facial BOTOX injection on symptoms of depression alongside its effects on beauty preservation"],"prefix":"10.1111","volume":"20","author":[{"given":"Mohammad","family":"Khademi","sequence":"first","affiliation":[{"name":"Tehran University of Medical Sciences Tehran Iran<!--Query ID=\"q4\" Text=\"AUTHOR: Please check that authors and their affiliations are correct.\"-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masoumeh","family":"Roohaninasab","sequence":"additional","affiliation":[{"name":"Department of Dermatology Rasool Akram Medical Complex Iran University of Medical Sciences (IUMS) Tehran Iran<!--Query ID=\"q5\" Text=\"AUTHOR: Please provide Academic degrees for the missing authors.\"-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1249-4429","authenticated-orcid":false,"given":"Azadeh","family":"Goodarzi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Rasool Akram Medical Complex Iran University of Medical Sciences (IUMS) Tehran Iran<!--Query ID=\"q5\" Text=\"AUTHOR: Please provide Academic degrees for the missing authors.\"-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farnoosh","family":"Seirafianpour","sequence":"additional","affiliation":[{"name":"Student Research Comittee, School of Medicine Iran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milad","family":"Dodangeh","sequence":"additional","affiliation":[{"name":"Student Research Comittee, School of Medicine Iran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arash","family":"Khademi","sequence":"additional","affiliation":[{"name":"The British Board of Antiaging &amp; Integrated Medicine London 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