{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T09:57:38Z","timestamp":1770458258005,"version":"3.49.0"},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T00:00:00Z","timestamp":1613952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sixty years ago, Ross discussed the use of oral dapsone in the treatment of acne vulgaris. Ross was fundamental in demonstrating the importance of this medication in dermatology. Following this, topical formulations have been used for the treatment of acne vulgaris which has not responded to traditional therapies. We explore the impact that the discovery of dapsone has had on subsequent research and clinical practice and explore the typical doses and side effects of this often sidelined therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a review of the literature on the use of dapsone for acne using key terms \u201cacne vulgaris,\u201d \u201cdapsone,\u201d \u201cisotretinoin,\u201d \u201csystemic,\u201d \u201ctopical\u201d searching databases such as MEDLINE, EMBASE, and PubMed. Only articles in English were chosen. The level of evidence was evaluated and selected accordingly listing the studies with the highest level of evidence first using the Oxford Centre of Evidence\u2010Based Medicine 2011 guidance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Oral dapsone and topical dapsone have been used in acne vulgaris and acne fulminans. Systemic dapsone seems to be less effective than other treatment options, and further research is required to examine the use of the topical formulation for acne vulgaris compared with alternative treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Dermatologists may wish to consider the use of this long\u2010established medication for the treatment of acne vulgaris. With careful monitoring, oral dapsone is an important alternative therapy where isotretinoin is contraindicated or not tolerated.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14011","type":"journal-article","created":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T14:50:48Z","timestamp":1613659848000},"page":"2036-2039","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Dapsone for acne: Still in use after half a century!"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5303-6881","authenticated-orcid":false,"given":"Tamara","family":"Searle","sequence":"first","affiliation":[{"name":"University of Birmingham Medical School Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0684-4322","authenticated-orcid":false,"given":"Firas","family":"Al\u2010Niaimi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Aalborg University Hospital Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faisal R.","family":"Ali","sequence":"additional","affiliation":[{"name":"Dermatological Surgery &amp; Laser Unit St John\u2019s Institute of Dermatology Guy\u2019s Hospital Cancer Centre Guy\u2019s and St Thomas\u2019 NHS Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,2,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1961.tb14398.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-013-1409-7"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.317.7152.181"},{"issue":"1","key":"e_1_2_9_5_1","first-page":"50","article-title":"Dapsone\u2010induced photodermatitis in a patient with linear IgA dermatosis","volume":"11","author":"St\u00f6ckel S","year":"2001","journal-title":"Eur J Dermatol"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1995.tb05022.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1988.tb00659.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12142"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12406"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.10.005"},{"issue":"5","key":"e_1_2_9_11_1","doi-asserted-by":"crossref","first-page":"AB2","DOI":"10.1016\/j.jaad.2016.02.007","article-title":"Age and gender as predictors of treatment outcomes with once\u2010daily dapsone 7.5% topical gel for acne vulgaris (abstract no. 3244 plus poster)","volume":"74","author":"Draelos ZD","year":"2016","journal-title":"J Am Acad Dermatol"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-016-0242-0"},{"issue":"5","key":"e_1_2_9_13_1","first-page":"553","article-title":"Efficacy and safety of once\u2010daily dapsone gel, 7.5% for treatment of adolescents and adults with acne vulgaris: first of two identically designed, large, multicenter, randomized, vehicle\u2010controlled trials","volume":"15","author":"Stein Gold LF","year":"2016","journal-title":"J Drugs Dermatol"},{"issue":"8","key":"e_1_2_9_14_1","first-page":"962","article-title":"Efficacy and safety of once\u2010daily dapsone gel 7.5% for treatment of adolescents and adults with acne vulgaris: second of two identically designed, large, multicenter, randomized, vehicle\u2010controlled trials","volume":"15","author":"Eichenfield LF","year":"2016","journal-title":"J Drugs Dermatol"},{"issue":"8","key":"e_1_2_9_15_1","first-page":"45","article-title":"Management of truncal acne vulgaris with topical dapsone 7.5% gel","volume":"11","author":"Del Rosso JQ","year":"2018","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-3354"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.1997.1830600.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0365-05962012000400015"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000324226"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14011","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.14011","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T18:10:21Z","timestamp":1709316621000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.14011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,22]]},"references-count":18,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1111\/jocd.14011"],"URL":"https:\/\/doi.org\/10.1111\/jocd.14011","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,22]]},"assertion":[{"value":"2021-01-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}