{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T07:36:05Z","timestamp":1751528165291,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T00:00:00Z","timestamp":1615248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Langerhans cells (LCs) are antigen\u2010presenting cells that are characterized by CD1a and CD207\/langerin expression. The disturbance in the communication network among keratinocytes, melanocytes, and antigen\u2010presenting cells may be involved in vitiligo pathogenesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The current work aims to detect and quantify LCs in involved skin of patients affected by vitiligo before and after treatment with NB\u2010UVB using CD1a immunohistochemistry, in addition to correlate percentage of LCs with the clinicopathological parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty vitiligo patients and 10 age and sex matched controls were investigated. Patients were received NB\u2010UVB thrice weekly for 12\u00a0weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a significant reduction in LCs percentage in skin affected by vitiligo before treatment in comparison with normal skin. About 65% (13\/20) of vitiligo patients responded to NB\u2010UVB, and the liability to respond was correlated with LCs percentage in specimens before treatment. However, there was no statistical difference between specimens before and after treatment regarding LCs percentage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Reduction in LCs in vitiligo may be a sign of active disease and melanocytes destruction. The percentage of LCs affects response to NB\u2010UVB since higher percentage is associated with greater response to therapy. Therefore, modulation of LCs as a type of immunotherapy could be beneficial in improvement of vitiligo.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14012","type":"journal-article","created":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T08:04:22Z","timestamp":1613808262000},"page":"3642-3648","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Evaluation of the Langerhans cells role in vitiligo and its relationship to NB\u2010UVB"],"prefix":"10.1111","volume":"20","author":[{"given":"Mohammed","family":"Shoeib","sequence":"first","affiliation":[{"name":"Department of Dermatology, Andology and STDs Faculty of Medicine Menoufia University Shebein Elkom Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azza Gaber Antar","family":"Farag","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Andology and STDs Faculty of Medicine Menoufia University Shebein Elkom 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