{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T20:08:49Z","timestamp":1770754129396,"version":"3.50.0"},"reference-count":39,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T00:00:00Z","timestamp":1614643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There are pieces of evidence regarding the association between melasma and metabolic syndrome. To assess the prevalence and grade of nonalcoholic fatty liver and lipid profile status in patients with melasma, we designed this case\u2010control study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was performed on 30 consecutive women with melasma who referred to the dermatology clinic of the hospital as the case group and 34 healthy women. For all participants, serum lipid profiles and liver enzymes were checked. Also, the existence of fatty liver was assessed by ultrasonography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Except for serum level of <jats:italic>LDL (low<\/jats:italic>\u2010<jats:italic>density lipoprotein)<\/jats:italic> that was significantly higher in the melasma group than in the healthy group (104.23\u00a0\u00b1\u00a025.00\u00a0mg\/dl versus 89.85\u00a0\u00b1\u00a023.00\u00a0mg\/dl, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.020), the level of other parameters including other lipid profiles, blood sugar, or liver enzymes was similar in both groups. In ultrasonography, the overall prevalence of fatty liver was 23.3% in the melasma group and 20.6% in the control group, and no difference was found between the two groups in grade of fatty liver (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.791).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The study showed a higher serum LDL level in patients with melasma compared to women without melasma, but there was no difference between the groups in prevalence or grade of fatty liver.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14014","type":"journal-article","created":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T14:05:51Z","timestamp":1613829951000},"page":"3656-3660","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Non\u2010alcoholic fatty liver and lipid profile status in patients with melasma: A case\u2010control study"],"prefix":"10.1111","volume":"20","author":[{"given":"Mohammadreza","family":"Ghassemi","sequence":"first","affiliation":[{"name":"Dermatology Department Rasool Akram Medical Complex Iran University of Medical Sciences (IUMS) Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saba","family":"Hosseinchi","sequence":"additional","affiliation":[{"name":"Iran University of Medical Sciences (IUMS) Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farnoosh","family":"Seirafianpour","sequence":"additional","affiliation":[{"name":"Student Research Committee School of Medicine Iran University of Medical Sciences (IUMS) Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milad","family":"Dodangeh","sequence":"additional","affiliation":[{"name":"Student Research Committee School of Medicine Iran University of Medical Sciences (IUMS) Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1249-4429","authenticated-orcid":false,"given":"Azadeh","family":"Goodarzi","sequence":"additional","affiliation":[{"name":"Dermatology Department Rasool Akram Medical Complex Iran University of Medical Sciences (IUMS) Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05660"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.13.s8.28.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(18)30663-6"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2004.11.041"},{"key":"e_1_2_10_6_1","first-page":"1224","volume-title":"Patologia: Bases Cl\u00ednico\u2010Patol\u00f3gicas da Medicina","author":"Storm CA","year":"2006"},{"key":"e_1_2_10_7_1","first-page":"567","article-title":"Genetics of pigment cells: lessons from the tyrosinase gene family","volume":"2","author":"Murisier F","year":"2006","journal-title":"Histol Histopathol"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1995.01690240119022"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2007.05.004"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.84722"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.12.046"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.1995.tb00341.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/15569527.2013.834496"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.4330\/wjc.v6.i6.462"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.30159.x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.15275\/rusomj.2020.0202"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2010.04.003"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm_00000487"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/147323001204000311"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.4274\/Jcrpe.825"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.07.028"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.41500.x"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.109"},{"issue":"3","key":"e_1_2_10_24_1","first-page":"3","article-title":"Assessment of Circulating Biochemical Markers and Antioxidative Status in patients suffering from Melasma","volume":"9","author":"Shuja AMN","year":"2015","journal-title":"Pakistan J Med Health Sci"},{"issue":"9","key":"e_1_2_10_25_1","article-title":"Metabolic syndrome and the skin: a morethan superficial association. 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