{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T13:56:46Z","timestamp":1788184606065,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T00:00:00Z","timestamp":1616025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acne is a chronic disease that affects the pilosebaceous follicle and is characterized by the presence of non\u2010inflammatory and\/or inflammatory lesions, affecting both adolescents and adults. Inflammatory acne lesions are capable to increase their melanin production and promote a post\u2010inflammatory hyperchromia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To assess the efficacy of a serum containing dioic acid, glycolic acid, salicylic acid, LHA, citric acid, and HEPES in treating post\u2010inflammatory hyperpigmentation and controlling skin oiliness in Brazilian patients with acne vulgaris.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients\/Methods<\/jats:title>\n                    <jats:p>\n                      A single\u2010center, prospective, open\u2010label clinical study included 42 subjects, from both genders, presenting acne (grade I or II), oily skin and a clinical diagnosis of acne post\u2010inflammatory hyperpigmentation. The study was conducted for 56\u00a0days, with clinical (skin quality and the number of post\u2010inflammatory hyperchromic lesions) and instrumental (Sebumetry) evaluations after 7, 28, and 56\u00a0days of treatment. Standardized pictures were obtained using a VISIA\u20106\n                      <jats:sup>\u00ae<\/jats:sup>\n                      device.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A significant decrease in the grade of post\u2010inflammatory hyperchromic lesions was observed after 28 and 56\u00a0days, while the number of lesions decreases by 29.4% after 56\u00a0days (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Sebumetry values showed a significant decrease of 30.7% in the oiliness after 7\u00a0days of treatment, and then stable during the study conduction period of 56\u00a0days (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001 for all measurements).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The daily treatment using the investigational product showed an interesting decrease both in the grade and the number of post\u2010inflammatory hyperchromia acne lesions after 56\u00a0days, and in the oiliness after 7\u00a0days, being stable for all study period.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.14016","type":"journal-article","created":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T14:51:00Z","timestamp":1614005460000},"page":"1766-1773","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Clinical evaluation of the efficacy of a facial serum containing dioic acid, glycolic acid, salicylic acid, LHA, citric acid, and HEPES in treating post\u2010inflammatory hyperchromia and controlling oily skin in patients with acne vulgaris"],"prefix":"10.1111","volume":"20","author":[{"given":"Valeria","family":"Campos","sequence":"first","affiliation":[{"name":"Mogi das Cruzes University S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiza","family":"Pitassi","sequence":"additional","affiliation":[{"name":"Unicamp S\u00e3o Paulo 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acid compouds having anti\u2010inflammatory properties. United States Patent. Number: 6 114 337. Date: Sep 5 2000."},{"issue":"3","key":"e_1_2_9_22_1","first-page":"S20","article-title":"Etiopathogeny of acne vulgaris: a practical review for day\u2010to\u2010day dermatologic practice","volume":"7","author":"Ribeiro BDM","year":"2015","journal-title":"Surg Cosmet Dermatol"},{"key":"e_1_2_9_23_1","first-page":"2283","article-title":"Combination therapy with retinaldehyde (0.1%) glycolic acid (6%) and efectiose (0.1%) in mild to moderate acne vulgaris during the period of sun exposure \u2013 efficacy and skin tolerability","volume":"18","author":"Masini F","year":"2014","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12895-015-0036-8"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1794"},{"key":"e_1_2_9_26_1","first-page":"497","volume-title":"Tratado Internacional de Cosmec\u00eauticos","author":"Costa A","year":"2012"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14016","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.14016","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T07:33:14Z","timestamp":1692948794000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.14016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,18]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1111\/jocd.14016"],"URL":"https:\/\/doi.org\/10.1111\/jocd.14016","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,18]]},"assertion":[{"value":"2020-05-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}