{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:52:59Z","timestamp":1791312779031,"version":"4.3.1"},"reference-count":40,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T00:00:00Z","timestamp":1614816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pathophysiology of rosacea is not completely understood and involves a complex interaction among genetics, ultraviolet (UV) light, microorganisms, impaired skin barrier, neuronal and vascular dysfunction, and immune system disruption.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To describe the etiology of rosacea with an emphasis on the role of UV radiation and exposome, and to review the importance of non\u2010pharmacologic strategies focusing on photoprotection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a narrative review of the literature. We performed literature searches with PubMed from January 1990 to November 2020 using the keywords \u201crosacea\u201d, \u201cpathogenesis\u201d, \u201cultraviolet radiation\u201d, \u201cexposome\u201d, \u201cphotoprotection\u201d, \u201csunscreens\u201d and \u201cnon\u2010pharmacologic agents\u201d. The search was limited to English, Spanish, and French language articles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Several environmental factors such as UV light, diverse microorganisms, air pollution, tobacco smoking, nutrition, and psychological stress showed to trigger or worsen rosacea. UV radiation was reported to induce pro\u2010inflammatory, pro\u2010angiogenic, and pro\u2010fibrotic responses. We found 6 original articles about the impact of sunscreens on rosacea. The use of sunscreens containing ingredients with emollient, anti\u2010inflammatory, and\/or vasoregulatory properties was shown to significantly improve symptomatology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>UV radiation and the exposome play a key role in the development of rosacea. UV light is implicated in all significant aspects of rosacea: skin inflammation, neoangiogenesis, telangiectasia, and fibrosis, and may even initiate rosacea. While the use of sunscreens is widely recommended, the literature on the impact of photoprotection in rosacea is scarce. Adequately formulated sunscreens could not only provide the required level of photoprotection, but may also help to mitigate the barrier dysfunction, neutralize facial redness (tinted sunscreens), and decrease inflammation and vascular dysfunction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14020","type":"journal-article","created":{"date-parts":[[2021,2,24]],"date-time":"2021-02-24T20:39:52Z","timestamp":1614199192000},"page":"3415-3421","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Impact of ultraviolet radiation and exposome on rosacea: Key role of photoprotection in optimizing treatment"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4704-6132","authenticated-orcid":false,"given":"Daniel","family":"Morgado\u2010Carrasco","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital Cl\u00ednic de Barcelona Universitat de Barcelona Barcelona 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