{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T16:05:12Z","timestamp":1783699512786,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T00:00:00Z","timestamp":1615334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Melasma has a complex pathogenesis, and various aggravating factors contribute to its recalcitrance to treatments. A combination of isobutylamido thiazolyl resorcinol (ITR) and hyaluronic acid (HA) could increase melasma treatment efficacy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To compare the efficacy and safety of 0.15% ITR plus HA vs 0.15% ITR or HA alone in melasma treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ninety\u2010two patients received ITR 0.15% plus HA (<jats:italic>n<\/jats:italic>\u00a0=\u00a030), 0.15% ITR (<jats:italic>n<\/jats:italic>\u00a0=\u00a031), or HA (<jats:italic>n<\/jats:italic>\u00a0=\u00a031) along with broad\u2010spectrum sunscreen application for 12\u00a0weeks. Treatment efficacy was determined using modified Melasma Area Severity Index (mMASI), average melanin and melanin variation with Antera3D<jats:sup>\u00ae<\/jats:sup>, and safety based on transepidermal water loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with the HA group, the ITR+HA group showed significantly reduced mMASI at weeks 4, 8, and 12 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.026, 0.015, and 0.001, respectively), whereas the ITR group showed a significant reduction at week 12 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.027). There was no significant difference in the mMASI or average melanin level between the ITR+HA and ITR groups. Melanin variation was significantly lower in the ITR+HA group than in the ITR group at weeks 4, 8, and 12 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.027, 0.019, and 0.023, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The combination of 0.15% ITR and 0.15% ITR+HA effectively reduced melasma severity. HA could synergistically improve melasma homogeneity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14031","type":"journal-article","created":{"date-parts":[[2021,2,27]],"date-time":"2021-02-27T16:37:43Z","timestamp":1614443863000},"page":"3563-3572","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Efficacy and safety of 0.15% isobutylamido thiazolyl resorcinol combined with hyaluronic acid vs 0.15% isobutylamido thiazolyl resorcinol or hyaluronic acid alone in melasma treatment: A randomized evaluator\u2010blind trial"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7843-4915","authenticated-orcid":false,"given":"Wareeporn","family":"Disphanurat","sequence":"first","affiliation":[{"name":"Division of Dermatology Department of Medicine Thammasat University Pathum Thani 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