{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:41:26Z","timestamp":1791484886379,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,4,17]],"date-time":"2021-04-17T00:00:00Z","timestamp":1618617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Topical tacrolimus is increasingly used nowadays in the treatment of vitiligo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We evaluated therapeutic outcomes of tacrolimus 0.03% in non\u2010segmental vitiligo (NSV).<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>Sixty\u2010three patients with NSV were divided into groups A and B. Group A received 0.03% tacrolimus ointment (n\u00a0=\u00a031) and group B received 1% hydrocortisone acetate ointment (n\u00a0=\u00a032) for 24\u00a0weeks. Vitiligo area and severity index (VASI) and repigmentation rates were determined at baseline and 4\u2010week intervals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In group A, 24\u2010week VASI [0.5 (0.3, 1.95)] was significantly lower than baseline VASI [0.75 (0.5, 2.1); <jats:italic>p<\/jats:italic>\u00a0=\u00a00.030]. In group B, 24\u2010week VASI [0.75 (0.4, 2.3)] was not significantly different from baseline VASI [0.73 (0.4, 2.1); <jats:italic>p<\/jats:italic>\u00a0=\u00a00.111]. Repigmentation was observed in 14\/31 (45.2%) of patients in group A versus 0\/32 (0.0%) in group B (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). Repigmentation was graded as poor in 6\/31 (19.4%), fair in 4\/31 (12.9%), good in 1\/31 (3.2%), and excellent in 3\/31 (9.7%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Repigmentation was achieved in 45% of patients with NSV following treatment with tacrolimus 0.03% monotherapy for 24\u00a0weeks. Tacrolimus\u2010induced repigmentation is more likely in patients with vitiligo vulgaris, head and neck lesions, skin phototype III, and young age.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14041","type":"journal-article","created":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T17:11:18Z","timestamp":1614791478000},"page":"3943-3952","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Efficacy of topical tacrolimus 0.03% monotherapy in the treatment of non\u2010segmental vitiligo: a randomized, controlled trial"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0503-3533","authenticated-orcid":false,"given":"Ramadan","family":"Saleh","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology Faculty of Medicine Sohag University Sohag Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aml Abd\u2010Elaziz","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Dermatology Farshot Central Hospital Qena Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3328-1967","authenticated-orcid":false,"given":"Wafaa","family":"M Abd\u2010Elmagid","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology Faculty of Medicine Sohag University Sohag Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2010.01159.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000131485"},{"key":"e_1_2_8_4_1","first-page":"16399","article-title":"Vitiligo therapeutic advances","author":"Jimbow K","year":"1998","journal-title":"Dermatol Clin"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20164012"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1996.4"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.120942"},{"key":"e_1_2_8_8_1","first-page":"35582","article-title":"Tacrolimus in dermatologic disorders. 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