{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T01:53:22Z","timestamp":1774317202415,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T00:00:00Z","timestamp":1618444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acne vulgaris, a chronic inflammatory dermatosis, affects approximately 85% of adolescents and young adults.The level of vitamin D in acne patients and the effect on acne patients of a vitamin D supplementation have previously been documented; however, it remains to be disputed whether vitamin D deficiency is normal in acne patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This paper explores the relationship between vitamin D and acne levels and the advantageous implications of vitamin D supplements on acne.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From every database start date until December 2020, we checked the PubMed, EMBASE, MEDLINE and the Cochrane libraries. Case\u2010controls or randomized controlled trial reporting on the serum 25(OH)D level and the efficacy of vitamin D supplement to acne patients were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The serum 25(OH)D levels in acne patients is lower (standardized mean difference = \u22127.66\u00a0ng\/ml; 95% confidence interval (CI) = \u221210.92 to \u22124.40). Articles also revealed the prospect of a therapeutic breakthrough through the supplementing of vitamin D for acne patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our research offers a new guide in the field of acne prevention and health care.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14057","type":"journal-article","created":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T18:06:31Z","timestamp":1615399591000},"page":"3802-3807","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Vitamin D status and efficacy of vitamin D supplementation in acne patients: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7152-9997","authenticated-orcid":false,"given":"Meng","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Dermatology Plastic Surgery Hospital Chinese Academy of Medical 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