{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T07:06:06Z","timestamp":1781939166336,"version":"3.54.5"},"reference-count":45,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T00:00:00Z","timestamp":1615852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Perioral dermatitis is a common cutaneous condition characterized by acneiform facial eruptions often with an eczematous appearance. A granulomatous subtype exists in addition to the classic variant. While topical corticosteroids have been largely implicated in this condition, its etiology is not completely understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using the keywords \u201ccorticosteroids,\u201d \u201cdermatology,\u201d \u201cfusobacteria,\u201d \u201cperioral dermatitis,\u201d and \u201cperiorificial dermatitis,\u201d we searched the databases PubMed, MEDLINE, and EMBASE to find the relevant literature. Only articles in English were chosen. The level of evidence was evaluated and selected according to the highest level working our way downwards using the Oxford Centre of Evidence\u2010Based Medicine 2011 guidance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This systematic review found the strongest evidence to support topical corticosteroid misuse as the principal causative factor in the pathogenesis of perioral dermatitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In terms of treatment, further research is required to robustly investigate promising treatment options including tetracyclines, topical metronidazole, topical azelaic acid, adapalene gel, and oral isotretinoin.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14060","type":"journal-article","created":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T07:38:55Z","timestamp":1615361935000},"page":"3839-3848","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Perioral dermatitis: Diagnosis, proposed etiologies, and management"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5303-6881","authenticated-orcid":false,"given":"Tamara","family":"Searle","sequence":"first","affiliation":[{"name":"University of Birmingham Medical School Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faisal R.","family":"Ali","sequence":"additional","affiliation":[{"name":"Dermatological Surgery &amp; Laser Unit St John\u2019s Institute of Dermatology Guy\u2019s and St Thomas\u2019 NHS Foundation Trust London 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