{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:47:31Z","timestamp":1791474451818,"version":"4.3.4"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T00:00:00Z","timestamp":1618531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Excessive sweating is considered primary hyperhidrosis if it is triggered by emotional states without any thermogenic or other underlying disease from the eccrine glands. This may be due to dysfunction in the autonomic nervous system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To investigate the relationship between Vitamin D and Mg deficiency and the risk of anxiety and depression in patients with primary hyperhidrosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>This cross\u2010sectional, case\u2010control study was conducted between July and October 2019. 49 primary hyperhidrosis patients in Group I and 47 age and gender matched healthy individuals in Group II were included in the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean 25 (OH) D and Mg levels in Group I were statistically significantly lower than in Group II (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001 and <jats:italic>p<\/jats:italic>\u00a0=\u00a00.002, respectively). Statistically significant differences were found between the groups in terms of anxiety and depression (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001 and <jats:italic>p<\/jats:italic>\u00a0=\u00a00.033, respectively). There was no significant relationship between the HADS\u2010A \/ HADS\u2010D scores and the severity of primary hyperhidrosis (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.131, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.096; correlation coefficient\u00a0=\u00a00.232, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.447). However, a significant correlation was observed between HADS\u2010A scores and serum Mg levels (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.439, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.007).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Anxiety and depression are common in patients with primary hyperhidrosis. As shown in this study, both anxiety and depression can be seen with low Mg levels in patients with primary hyperhidrosis. This could possibly be related to the pathological mechanism involving Vitamin D and Mg, which determines the common pathway affecting primary hyperhidrosis and anxiety\/depression.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14075","type":"journal-article","created":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T06:26:00Z","timestamp":1616135160000},"page":"373-379","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of the serum magnesium and vitamin D levels and the risk of anxiety in primary hyperhidrosis"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0044-7414","authenticated-orcid":false,"given":"Vildan","family":"Manav","sequence":"first","affiliation":[{"name":"Department of Dermatology \u0130stanbul Training and Research Hospital \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cemre B\u00fc\u015fra","family":"T\u00fcrk","sequence":"additional","affiliation":[{"name":"Department of Dermatology \u0130stanbul Training and Research Hospital \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asude","family":"Kara Polat","sequence":"additional","affiliation":[{"name":"Department of Dermatology \u0130stanbul Training and Research Hospital \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duygu","family":"Erdil","sequence":"additional","affiliation":[{"name":"Department of Dermatology \u0130stanbul Training and Research Hospital \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soysal","family":"Ba\u015f","sequence":"additional","affiliation":[{"name":"Department of Plastic Reconstructive and Aesthetic Surgery \u0130stanbul Hamidiye \u015ei\u015fli Etfal Training and Research Hospital \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ay\u015fe Esra","family":"Koku Aksu","sequence":"additional","affiliation":[{"name":"Department of Dermatology \u0130stanbul Training and Research Hospital \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2003.01162.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.12.071"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20142189"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-017-0693-x"},{"issue":"3","key":"e_1_2_9_6_1","first-page":"221","article-title":"Serum vitamin D and magnesium levels in a psychiatric cohort","volume":"31","author":"Woodward G","year":"2019","journal-title":"Psychiatr 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