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It is formed by progressive dilatation of post\u2010capillary venules and is associated with hypertrophy and nodularity with increasing age, leading to cosmetic disfigurement and psychological aggravation. It is caused by genetic mosaicism in GNAQ and GNA11 genes. Histopathology is the gold standard for assessment of PWS but it is invasive and may cause scarring. Inadequate characterization of the lesions may predispose to inadequate treatment protocols as well as higher treatment dosages. Clinical evaluation of treatment efficacy is subjective and may not be a representative of actual results. Therefore, an objective visualization modality is required. With evolving technology, numerous optical instruments have been developed for objective evaluation and visualization of subsurface structures. These include VISIA\u2010CR\u2122 system, videodermoscopy, high\u2010frequency ultrasound (HFUS), laser speckle contrast imaging (LSCI), reflectance spectrophotometers and tristimulus colorimeter, laser Doppler flowmetry (LDF), cross\u2010polarized diffuse reflectance imaging system (CDR), reflectance confocal microscopy (RCM), optical coherence tomography (OCT), and spatial frequency domain imaging (SFDI). These semi\u2010quantitative modes of diagnosis are complementary to each other. Some can be used in the clinical setting while others, due to high instrument cost, are limited to the research settings. In this review, we bring to you a brief overview of noninvasive diagnostic modalities in PWS.<\/jats:p>","DOI":"10.1111\/jocd.14087","type":"journal-article","created":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T11:06:34Z","timestamp":1617188794000},"page":"2006-2014","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Noninvasive diagnostic techniques of port wine stain"],"prefix":"10.1111","volume":"20","author":[{"given":"Jeta","family":"Buch","sequence":"first","affiliation":[{"name":"Private Practitioner  Ahmedabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Karagaiah","sequence":"additional","affiliation":[{"name":"Department of Dermatology Bangalore Medical College and Research Institute  Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prerana","family":"Raviprakash","sequence":"additional","affiliation":[{"name":"DVL Mysore 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