{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T04:47:43Z","timestamp":1776833263185,"version":"3.51.2"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,3,28]],"date-time":"2021-03-28T00:00:00Z","timestamp":1616889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Treatment of acanthosis nigricans (AN) is challenging, and new modalities are being explored continuously to increase the therapeutic efficacy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the efficacy and safety of fractional CO2 laser compared to trichloroacetic acid (TCA) peel in the treatment of pseudo\u2010acanthosis nigricans (pseudo\u2010AN).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study included 40 patients with pseudo\u2010AN on the neck and axilla allocated into two groups each containing 20 patients. Group (A) was treated with TCA 20% peel applied on the pigmented area while group (B) received fractional CO2 laser. Both treatments were performed till complete clearance or for a maximum of four treatment sessions. Patients with excellent response were further followed up for 6\u00a0months after the end of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both modalities were effective in the treatment of pseudo\u2010AN; however, the therapeutic response was significantly higher in the fractional CO2 laser group compared to the TCA peel group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01). Marked to excellent response (51%\u2013100% clearance of AN lesions) was achieved in 85% of the patients in the fractional laser group versus 10% of the patients in the TCA group. Adverse effects, for example, persistent erythema, post\u2010inflammatory hyperpigmentation, and burning sensation, were also statistically higher in the TCA group compared to the laser group (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Fractional CO2 laser is a promising effective and well\u2010tolerated treatment modality for pseudo\u2010acanthosis nigricans.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14088","type":"journal-article","created":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T13:56:06Z","timestamp":1616421366000},"page":"247-253","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Fractional carbon dioxide laser versus trichloroacetic acid peel in the treatment of pseudo\u2010acanthosis nigricans"],"prefix":"10.1111","volume":"21","author":[{"given":"Fatma","family":"Eldeeb","sequence":"first","affiliation":[{"name":"Dermatology, Venereology and Andrology Department Faculty of Medicine Zagazig University Zagazig Egypt"},{"name":"Member of Interactive Dermatology Research Foundation Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reham M.","family":"Wahid","sequence":"additional","affiliation":[{"name":"Physiology Department Zagazig University Zagazig Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3907-087X","authenticated-orcid":false,"given":"Rania","family":"Alakad","sequence":"additional","affiliation":[{"name":"Dermatology, Venereology and Andrology Department Faculty of Medicine Zagazig University Zagazig Egypt"},{"name":"Member of Interactive Dermatology Research Foundation Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-196801000-00002"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12276922"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1976.tb04895.x"},{"issue":"4","key":"e_1_2_7_5_1","first-page":"290","article-title":"Comparison of long\u2010pulsed alexandrite laser and topical tretinoin\u2010ammonium lactate in axillary acanthosis nigricans: a case series of patients in a before\u2010after trial","volume":"7","author":"Ehsani A","year":"2016","journal-title":"Caspian J Intern Med"},{"issue":"2","key":"e_1_2_7_6_1","first-page":"170","article-title":"To compare the efficacy and safety of trichloroacetic acid peel with topical tretinoin in the treatment of acanthosis nigricans: a randomized controlled 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