{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:12:22Z","timestamp":1787015542212,"version":"build-2736575974"},"reference-count":11,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"vor","delay-in-days":30,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Diaper dermatitis (DD) is an acute inflammatory reaction, regardless of the cause, of the diaper\u2010covered area. Topical skin barrier repair cosmetic products are the mainstay treatment to cure and\/or prevent DD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      To assess the efficacy\/tolerability of a zinc gluconate\u2010taurine\/zinc oxide and panthenol\/ glycerin\/\n                      <jats:italic>Butyrospermum parkii<\/jats:italic>\n                      butter barrier cream using clinical evaluation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective, open\u2010label trial, 20 patients (10 infants\/10 adults), with mild\/moderate DD enrolled at the Dermatology University Clinic of Catania (Italy) were instructed to apply the cream twice daily for 30\u00a0days. Degree of erythema was performed clinically by a 5\u2010point severity scale (from 0\u00a0=\u00a0no erythema to 4\u00a0=\u00a0severe erythema), at baseline, at 15 and 30\u00a0days. An Investigator Global Assessment (IGA) using a 6\u2010point scale (from \u22121\u00a0=\u00a0worsening to 4\u00a0=\u00a0complete response\/clear) along with product tolerability was also performed at 15 and 30\u00a0days. Statistical analysis was performed using SAS version 9.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At 15\u00a0days, a reduction of clinical erythema assessment (CEA) from baseline was observed (mean from 3.2\u00a0\u00b1\u00a00.8 to 2.5\u00a0\u00b1\u00a00.3;\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.06), that although nonsignificant, showed a significant progressive improvement at 30\u00a0days (mean from 3.2\u00a0\u00b1\u00a00.8 to 1.1\u00a0\u00b1\u00a00.9;\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.0001) without any age differences.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our preliminary results indicate that the tested barrier cream may represent a promising approach in DD rash. It may be used in mild\u2010to\u2010moderate forms in monotherapy without significant side effects or, where required, in association with pharmacological agents. Its long\u2010term use is likely safe.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.14091","type":"journal-article","created":{"date-parts":[[2021,5,2]],"date-time":"2021-05-02T01:46:31Z","timestamp":1619919991000},"page":"1-4","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["A novel treatment of diaper dermatitis in children and adults"],"prefix":"10.1111","volume":"20","author":[{"given":"Federica","family":"Dall\u2019Oglio","sequence":"first","affiliation":[{"name":"Dermatology Clinic University of Catania  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Letizia","family":"Musumeci","sequence":"additional","affiliation":[{"name":"Dermatology Clinic University of Catania  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide Francesco","family":"Puglisi","sequence":"additional","affiliation":[{"name":"Dermatology Clinic University of Catania  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Micali","sequence":"additional","affiliation":[{"name":"Dermatology Clinic University of Catania  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.13748"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2015.04.012"},{"issue":"1","key":"e_1_2_8_4_1","first-page":"106","article-title":"Diaper dermatitis in elderly","volume":"2","author":"Bonifazi A","year":"2017","journal-title":"J Dermatitis"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.13495"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/709152"},{"key":"e_1_2_8_7_1","unstructured":"Zinc\u2010gluconate. [Access date 2021 Jan 25].https:\/\/thedermreview.com\/zinc\u2010gluconate"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-012-1361-4"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2014.02.012"},{"issue":"4","key":"e_1_2_8_10_1","first-page":"361","article-title":"Skin moisturizing effects of panthenol\u2010based formulations","volume":"62","author":"Camargo FB","year":"2011","journal-title":"J Cosmet Sci"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15602"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1515\/1553-3840.1574"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14091","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.14091","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14091","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T22:23:23Z","timestamp":1692829403000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.14091"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":11,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1111\/jocd.14091"],"URL":"https:\/\/doi.org\/10.1111\/jocd.14091","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"2021-03-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}