{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T05:21:02Z","timestamp":1793683262364,"version":"4.5.1"},"reference-count":17,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"vor","delay-in-days":30,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cradle cap is a benign and self\u2010limiting variant of seborrheic dermatitis (SD) that can be distressing for parents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To assess by clinical\/laboratory\/instrumental evaluation the efficacy\/tolerability of a gel cream containing piroctone olamine (antifungal), biosaccharide gum\u20102 (antifungal), stearyl glycyrrhetinate (anti\u2010inflammatory), and zinc l\u2010pyrrolidone carboxylate (zinc\u2010PCA) (antiseborrheic) in the treatment of mild\/ moderate cradle cap.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this prospective, open\u2010label trial, 10 infants, with mild\/moderate cradle cap enrolled at the Dermatology University Clinic of Catania (Italy) used the tested gel cream twice daily for 30\u00a0days. Degree of erythema was evaluated clinically by a 5\u2010point severity scale (from 0=no erythema to 4=severe erythema), at baseline, at 15 and 30\u00a0days. Desquamation was rated by dermoscopy evaluation using a 5\u2010point scale (from 0=no desquamation to 4=severe\/many large adherent white flakes), at all time points. An Investigator Global Assessment (IGA) using a 6\u2010point scale (from \u22121=worsening to 4=complete response\/clear) was also performed at 30\u00a0days. Five subjects, randomly selected, underwent double microbiological evaluation for bacteria and yeasts by cultures of cotton swabs at baseline and at 30\u00a0days. Tolerability\/acceptability was evaluated on a 4\u2010point scale (from 0=very poor to 3=excellent) at 15 and 30\u00a0days. Data were processed using SAS version 9.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, a significant colony\u2010forming unit (CFU) count for <jats:italic>Malassezia furfur<\/jats:italic> and <jats:italic>Staphylococcus aureus<\/jats:italic> was detected in 4 out of 5 selected patients. After 15 and 30\u00a0days, a statically significant reduction from baseline in erythema and desquamation severity was observed, along with a reduction in CFU count for <jats:italic>Malassezia furfur and Staphylococcus aureus<\/jats:italic> from baseline. No signs of local side effects were documented.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results indicate that the tested gel cream may represent a valid option to treat mild\u2010to\u2010moderate forms of cradle cap and support its antifungal and antibacterial properties.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14095","type":"journal-article","created":{"date-parts":[[2021,5,2]],"date-time":"2021-05-02T05:46:31Z","timestamp":1619934391000},"page":"14-17","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Treatment of cradle cap in infants with a new cosmetic non\u2010steroidal gel cream: Clinical, laboratory, and instrumental evaluation"],"prefix":"10.1111","volume":"20","author":[{"given":"Giuseppe","family":"Micali","sequence":"first","affiliation":[{"name":"Dermatology Clinic University of Catania  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nella","family":"Pulvirenti","sequence":"additional","affiliation":[{"name":"Dermatology Clinic University of Catania  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Dall\u2019Oglio","sequence":"additional","affiliation":[{"name":"Dermatology Clinic University of Catania  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurora","family":"Tedeschi","sequence":"additional","affiliation":[{"name":"Dermatology Clinic University of Catania  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrica","family":"Quattrocchi","sequence":"additional","affiliation":[{"name":"Dermatology Department Mayo Clinic Rochester  MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Lacarrubba","sequence":"additional","affiliation":[{"name":"Dermatology Clinic University of Catania  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"NoblesT HarbergerS KrishnamurthyK.Cradle Cap. 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PMID: 30285358."},{"key":"e_1_2_9_3_1","volume-title":"Seborrheic Dermatitis","author":"Micali G","year":"2015"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000444682"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10570.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13538"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14091"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.13870"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/1348-0421.12398"},{"key":"e_1_2_9_10_1","first-page":"CD008138","article-title":"Topical antifungals for seborrhoeic dermatitis","volume":"4","author":"Okokon E","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"issue":"3","key":"e_1_2_9_11_1","first-page":"CD011380","article-title":"Interventions for infantile seborrhoeic dermatitis (including cradle cap)","volume":"3","author":"Victoire A","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000439354"},{"issue":"4","key":"e_1_2_9_13_1","first-page":"448","article-title":"A double\u2010blind, placebo\u2010controlled pilot study to estimate the efficacy and tolerability of a nonsteroidal cream for the treatment of cradle cap (seborrheic dermatitis)","volume":"12","author":"David E","year":"2013","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12185"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2362"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2494.2011.00676.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-019-00339-w"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-019-0311-4"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14095","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.14095","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14095","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T02:23:06Z","timestamp":1692843786000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.14095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":17,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1111\/jocd.14095"],"URL":"https:\/\/doi.org\/10.1111\/jocd.14095","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"2021-05-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}