{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T16:17:56Z","timestamp":1790093876542,"version":"4.0.1"},"reference-count":12,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"vor","delay-in-days":30,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,4]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Topical azelaic acid (AzA) is a common treatment for mild\/moderate inflammatory rosacea.<\/jats:p><\/jats:sec>Aims<\/jats:title>To assess the efficacy and tolerability of a novel formulation cream containing 15% AzA (anti\u2010inflammatory\/anti\u2010oxidant\/anti\u2010microbial agent) combined with 1% dihydroavenanthramide D (anti\u2010inflammatory\/anti\u2010itch) in inflammatory rosacea using clinical\/instrumental evaluation.<\/jats:p><\/jats:sec>Methods<\/jats:title>In this multicentre, prospective, open\u2010label trial, 45 patients with mild\/moderate inflammatory rosacea enrolled at the Dermatology Clinic of the University of Catania, Naples, and Rome (Italy) were instructed to apply the cream twice daily for 8\u00a0weeks. Clinical evaluation was performed at baseline (T0) and at 8\u00a0weeks (T1) by (1) Investigator Global Assessment (IGA) score based on a 5\u2010point scale (from 0\u00a0=\u00a0clear\/no erythema\/papules\/pustules to 4\u00a0=\u00a0severe erythema\/several papules\/pustules) and (2) inflammatory lesions count. Instrumental evaluation of erythema degree was performed by erythema\u2010directed digital photography (EDDP) by a 5\u2010point scale (from 0\u00a0=\u00a0no redness to 4\u00a0=\u00a0severe redness) at all time points. Tolerability was assessed by a self\u2010administered questionnaire at 8\u00a0weeks. Statistical analysis was performed using SAS version 9.<\/jats:p><\/jats:sec>Results<\/jats:title>Forty\u2010four patients completed the study. At week 8, a significant decrease in baseline of IGA scores [median from 3 (T0) to 1 (T1)] and inflammatory lesions count [median from 8 (T0) to 1 (T1)] was recorded along with a significant reduction of erythema scores [median from 2 (T0) to 1 (T1)]. No relevant side effects were recorded.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Our results suggest that this new non\u2010irritating product represents a valid therapeutic option for mild\/moderate inflammatory rosacea, and EDDP is able to provide a more defined evaluation of erythema changes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14098","type":"journal-article","created":{"date-parts":[[2021,5,2]],"date-time":"2021-05-02T05:46:31Z","timestamp":1619934391000},"page":"28-31","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["A\u00a0novel azelaic acid formulation for the topical treatment of inflammatory rosacea: A multicentre, prospective clinical trial"],"prefix":"10.1111","volume":"20","author":[{"given":"Federica","family":"Dall\u2019Oglio","sequence":"first","affiliation":[{"name":"Dermatology Clinic University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurora","family":"Tedeschi","sequence":"additional","affiliation":[{"name":"Dermatology Clinic University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Lacarrubba","sequence":"additional","affiliation":[{"name":"Dermatology Clinic University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Fabbrocini","sequence":"additional","affiliation":[{"name":"Section of Dermatology Department of Clinical Medicine and Surgery University Federico II of Naples Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nevena","family":"Skroza","sequence":"additional","affiliation":[{"name":"Dermatology Unit \u201cDaniele Innocenzi\u201d Department of Medical\u2010Surgical Sciences and Bio\u2010Technologies Sapienza University of Rome Terracina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Chiodini","sequence":"additional","affiliation":[{"name":"Medical Statistics Unit University of Campania \u201cLuigi Vanvitelli\u201d Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Micali","sequence":"additional","affiliation":[{"name":"Dermatology Clinic University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18420"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17091562"},{"issue":"4","key":"e_1_2_8_4_1","first-page":"CD003262","article-title":"Interventions for rosacea","volume":"2015","author":"Zuuren EJ","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"issue":"3","key":"e_1_2_8_5_1","first-page":"37","article-title":"Azelaic acid topical formulations: differentiation of 15% gel and 15% foam","volume":"10","author":"Del Rosso JQ","year":"2017","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12979"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2019.1572860"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-017-2318-3"},{"issue":"7","key":"e_1_2_8_9_1","first-page":"30","article-title":"Improving treatment of erythematotelangiectatic rosacea with laser and\/or topical therapy through enhanced discrimination of its clinical features","volume":"9","author":"Micali G","year":"2016","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13265"},{"issue":"3","key":"e_1_2_8_11_1","first-page":"316","article-title":"Efficacy and safety of ivermectin 1% cream in treatment of papulopustular rosacea: results of two randomized, double\u2010blind, vehicle\u2010controlled pivotal studies","volume":"13","author":"Stein L","year":"2014","journal-title":"J Drugs Dermatol"},{"issue":"9","key":"e_1_2_8_12_1","first-page":"964","article-title":"Azelaic acid: evidence\u2010based update on mechanism of action and clinical application","volume":"14","author":"Schulte BC","year":"2015","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_8_13_1","first-page":"1","article-title":"Emerging topical drugs for the treatment of rosacea","volume":"18","author":"Dall\u2019Oglio F","year":"2021","journal-title":"Expert Opin Emerg Drugs"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14098","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.14098","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14098","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T02:23:10Z","timestamp":1692843790000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.14098"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":12,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1111\/jocd.14098"],"URL":"https:\/\/doi.org\/10.1111\/jocd.14098","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"2021-03-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}