{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:42:20Z","timestamp":1790404940989,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T00:00:00Z","timestamp":1617753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Effects of low energy, single\u2010pass helium plasma dermal resurfacing (PDR) treatment on brown spots, enlarged pores, and wrinkles\u2014preliminary findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty two subjects (64.6\u00a0\u00b1\u00a06.6\u00a0years) with Fitzpatrick Wrinkle and Elastosis Scale score (FWS) of \u22642 and seeking improvement of facial appearance were included in this subanalysis. All subjects received a single, one\u2010pass, full face, and low power helium PDR treatment. Standard digital images were collected using the VISIA\u2010CR (Canfield Scientific Inc.) at baseline and 3\u00a0months after treatment with images assessed for improvement in FWS and for improvements in brown spots, enlarged pores, and wrinkles by proprietary automated image processing algorithms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nearly all subjects demonstrated \u22651\u2010point improvement in FWS and also reported improvement per modified Global Aesthetic Improvement Scale query. The numbers of brown spots and enlarged pores decreased by 45.1% and 28.3%, respectively. Stratification of brown spots data by presence or absence of post\u2010inflammatory hyperpigmentation revealed paradoxically conflicting data. The improvement detected in wrinkle area and mean wrinkle thickness was less pronounced with overall reductions of 13.4% and 4.8%, respectively. 37 Non\u2010serious adverse events (AEs) in 22 subjects were reported with most resolving within 14\u00a0days or less, and no serious AEs were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>While longer\u2010term follow\u2010up is needed, these early study results show that one single\u2010pass, low energy helium PDR treatment improves facial skin appearance both qualitatively and quantitatively. Studies evaluating higher energy levels and multiple treatment passes are ongoing.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14106","type":"journal-article","created":{"date-parts":[[2021,3,27]],"date-time":"2021-03-27T02:08:16Z","timestamp":1616810896000},"page":"1668-1678","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Helium plasma dermal resurfacing: VISIA CR assessment of facial spots, pores, and wrinkles\u2014Preliminary findings"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5402-9779","authenticated-orcid":false,"given":"John David","family":"Holcomb","sequence":"first","affiliation":[{"name":"Holcomb \u2010 Kreithen Plastic Surgery and Medspa Sarasota FL 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