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Recent studies have attempted to address recalcitrant and recurring melasma by combining energy\u2010based devices with topical or oral medications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This article reviews EBDs\u2010based augmented treatment for melasma and suggests practical pathogenesis\u2010oriented treatment regimens. Treatment algorithms are proposed to address various components of melasma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic PubMed search was conducted acquiring information from various studies on combination treatments of melasma involving EBDs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 286 retrieved articles were filtered by title to contain at least one type of energy\u2010based modality such as laser, IPL, or RF along with at least one other treatment method. Based on their subject matter, combinations were further categorized into the subheadings: laser plus medication, laser plus laser, and IPL\u2010 and RF\u2010containing treatment methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There are many energy\u2010based combination treatments that have been explored for mitigation of melasma including laser therapy with medication, multi\u2010laser therapies, IPL, RF, and microneedling devices. Melasma is an exceedingly difficult condition to treat, however, choosing the appropriate tailor\u2010made treatment combination can improve the final outcome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14110","type":"journal-article","created":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T17:40:51Z","timestamp":1617298851000},"page":"461-472","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["A review of combined treatments for melasma involving energy\u2010based devices and proposed pathogenesis\u2010oriented combinations"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2212-7075","authenticated-orcid":false,"given":"Joseph N.","family":"Mehrabi","sequence":"first","affiliation":[{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University  Tel\u2010Aviv 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