{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T20:17:13Z","timestamp":1780085833048,"version":"3.54.0"},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,4,24]],"date-time":"2021-04-24T00:00:00Z","timestamp":1619222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Min\u00e9ral 89 (M89), comprised of 89% Vichy mineralizing water and hyaluronic acid, has been formulated to help strengthen and restore skin barrier.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>Assess tolerance and efficacy of M89 in post\u2010esthetic procedures and dry skin\u2010related facial dermatoses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Adults post\u2010esthetic procedure or presenting with inflammatory dermatoses (47 subjects; mean age 40.9\u00a0\u00b1\u00a013.2\u00a0years; any Fitzpatrick or skin phototype), applied M89 for 4\u00a0weeks, once or twice daily, as an adjuvant treatment. Information on clinical signs and subject\u2010reported symptoms, skin characteristics, tolerance, and subject and investigator satisfaction were collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Following 4\u00a0weeks of M89 use, significant decreases with complete resolution of erythema (27.6%), desquamation (29.8%), irritation (32%), and skin dehydration (35.8%), as compared to baseline signs and symptoms, were observed. Overall grading improvements for erythema (84.8%; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), desquamation (91.7%; %; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.003), irritation (91.7%; %; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.015), and skin hydration (46.2%; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.015) were noted. There was no significant improvement in papules and pustules. Evaluation of subjective signs demonstrated significant decreases in skin sensations such as burning (\u221273%; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001), itching (\u221271%; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001), stinging\u2010tingling (\u221266.7%; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001), as well as in skin dryness (\u221260%; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001). M89 texture was rated very pleasant by 90% of patients. Investigators assessed M89 tolerance to be either good or very good (93%), and satisfactory or highly satisfactory impact on patient's skin (91.5%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>M89 is a highly tolerable adjuvant treatment that significantly improved clinical signs and symptoms related to a compromised skin barrier in various facial dermatoses and post\u2010aesthetic procedures.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14116","type":"journal-article","created":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T08:01:35Z","timestamp":1617177695000},"page":"2148-2155","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["89% Vichy mineralizing water with hyaluronic acid is a well\u2010tolerated adjunct treatment that helps restore skin barrier function in dry skin\u2010related inflammatory dermatoses and post\u2010procedure skin care: A Canadian study"],"prefix":"10.1111","volume":"20","author":[{"given":"Chih\u2010Ho","family":"Hong","sequence":"first","affiliation":[{"name":"Department of Dermatology and Skin Science University of British Columbia Surrey BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordana","family":"Schachter","sequence":"additional","affiliation":[{"name":"Department of Dermatology H\u00f4pital du Haut\u2010Richelieu Saint\u2010Jean\u2010sur\u2010Richelieu QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison B.","family":"Sutton","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Skin Science University of British Columbia Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer M.","family":"Salsberg","sequence":"additional","affiliation":[{"name":"Division of Dermatology University of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica K.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Skin Science University of British Columbia Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon D.","family":"Humphrey","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Skin Science University of British Columbia Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4329-2029","authenticated-orcid":false,"given":"Nour R.","family":"Dayeh","sequence":"additional","affiliation":[{"name":"Vichy Laboratoires Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,24]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"v","article-title":"Sensing the environment: regulation of local and global homeostasis by the skin's neuroendocrine system","volume":"212","author":"Slominski 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