{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T12:28:20Z","timestamp":1754396900523,"version":"3.40.5"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T00:00:00Z","timestamp":1620086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Several treatments have been used to reduce inflammation and to reverse epithelial alterations in actinic cheilitis (AC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>A systematic review was conducted to analyze the potential of topical treatments for remission and clinical improvement of AC as well as patient acceptability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic review of clinical trials was conducted following the PICO strategy to answer the following question: Are topical anti\u2010inflammatory and antineoplastic agents effective in the treatment of actinic cheilitis? The quality of the studies was assessed by ROB\u20102, and the certainty of evidence was rated by GRADE guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eight clinical trials were selected, including four that investigated the use of anti\u2010inflammatory drugs and four use of antineoplastic agents. The use of 3% diclofenac sodium was associated with partial remission of AC, while 5% imiquimod and ingenol mebutate promoted complete remission. Furthermore, 5% fluorouracil was the drug most associated with complications during treatment. Diclofenac sodium (3%) and fludroxycortide showed the best acceptance by the patients, especially in terms of symptom relief and comfort provided.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The anti\u2010inflammatory and antineoplastic agents analyzed largely provided good clinical outcomes, with evidence of remission of AC lesions, development of few local adverse reactions during treatment, and good patient adherence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14118","type":"journal-article","created":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T08:55:45Z","timestamp":1617180945000},"page":"473-481","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Use of topical anti\u2010inflammatory and antineoplastic agents in the treatment of young\u2010aged actinic cheilitis: A systematic review"],"prefix":"10.1111","volume":"21","author":[{"given":"Cristianne Kalinne Santos","family":"Medeiros","sequence":"first","affiliation":[{"name":"Postgraduate Program in Dental Sciences, Area of Concentration in Stomatology and Oral Pathology Federal University of Rio Grande do Norte Natal RN Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0483-6601","authenticated-orcid":false,"given":"Gl\u00f3ria Maria","family":"de Fran\u00e7a","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Dental Sciences, Area of Concentration in Stomatology and Oral Pathology Federal University of Rio Grande do Norte Natal RN Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jabes Gennedyr da Cruz","family":"Lima","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Dental Sciences, Area of Concentration in Stomatology and Oral Pathology Federal University of Rio Grande do Norte Natal RN Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana 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