{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:52:12Z","timestamp":1791507132476,"version":"4.3.4"},"reference-count":18,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T00:00:00Z","timestamp":1619568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T00:00:00Z","timestamp":1619568000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Platelet\u2010rich plasma (PRP) has been found to be effective in treating periorbital hyperpigmentation (POH). PRP prepared by double\u2010spin (DS) method and activated by calcium has been used conventionally. PRP can be prepared by single spin (SS) and activated at low temperature (novel method), but the evidence is limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare the novel and conventional PRP in the treatment of periorbital hyperpigmentation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We selected 21 patients of POH and randomly divided the face into two halves. One\u2010half of the face (group A) was treated with novel PRP (SS and low\u2010temperature activation). The other half (group B) was treated with conventional PRP (DS and calcium activation). A total of 3 PRP injections were given at 4 weekly intervals. Patients were observed and assessed on 12\n                      <jats:sup>th<\/jats:sup>\n                      week by photography, dermoscopy, visual analog scale (VAS) score, and Dermatology life quality index (DLQI). Platelet counts and growth factors were assessed in PRP.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mean platelet count in novel and conventional PRP was 7.41\u00a0\u00b1\u00a01.76 lacs and 8.17\u00a0\u00b1\u00a02.23 lacs (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.348). Mean photographic and dermoscopic assessment at the end of the study in group A and group B was 52.33\u00a0\u00b1\u00a06.468 and 53.14\u00a0\u00b1\u00a06.99 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.151). Change in VAS in groups A and B was 3.85\u00a0\u00b1\u00a01.27 and 3.90\u00a0\u00b1\u00a01.04 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.895). Levels of various growth factors assessed by ELISA did not differ significantly. There was significant decline in DLQI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The novel method is not inferior to conventional method of PRP in the treatment of periorbital hyperpigmentation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.14121","type":"journal-article","created":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T11:49:05Z","timestamp":1617277745000},"page":"3245-3252","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Comparing novel versus conventional technique of platelet\u2010rich plasma therapy in periorbital hyperpigmentation: A randomized prospective split\u2010face study"],"prefix":"10.1111","volume":"20","author":[{"given":"Anil","family":"Budania","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology, and Leprology All India Institute of Medical Sciences Jodhpur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saptarshi","family":"Mandal","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine and Blood Bank All India Institute of Medical Sciences Jodhpur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3462-1625","authenticated-orcid":false,"given":"Yashdeep Singh","family":"Pathania","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology, and Leprology All India Institute of Medical Sciences Jodhpur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Utkrist","family":"Lahoria","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology, and Leprology All India Institute of Medical Sciences Jodhpur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Atik","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine and Blood Bank All India Institute of Medical Sciences Jodhpur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inder","family":"Puri","sequence":"additional","affiliation":[{"name":"Department of Neurology Sardar Patel Medical College Bikaner Rajasthan India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richa","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine and Blood Bank All India Institute of Medical Sciences Jodhpur India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2165.2007.00324.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2009.01213.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000665"},{"key":"e_1_2_10_5_1","first-page":"49","article-title":"Periorbital hyperpigmentation: a comprehensive review","volume":"9","author":"Sarkar R","year":"2016","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2014.26.3.401"},{"key":"e_1_2_10_7_1","article-title":"Response to intradermal autologous platelet rich plasma injection in refractory dermal melasma: report of two cases","volume":"18","author":"Ch Y","year":"2015","journal-title":"J Health Transl Med"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsm.2010.079822"},{"key":"e_1_2_10_9_1","first-page":"725","volume-title":"AABB Technical Manual","author":"American Association of Blood Banks technical manual committee","year":"1999"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/biores.2013.0015"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V30.5.625.625"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000477353"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2011.02065.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.159946"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH03-07-0440"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12478"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12072"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.5923\/j.ajdv.20140305.03"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/term.2832"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14121","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.14121","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14121","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:46:22Z","timestamp":1791506782000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.14121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,28]]},"references-count":18,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1111\/jocd.14121"],"URL":"https:\/\/doi.org\/10.1111\/jocd.14121","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,28]]},"assertion":[{"value":"2020-09-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}