{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:57:20Z","timestamp":1792173440694,"version":"4.4.0"},"reference-count":32,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T00:00:00Z","timestamp":1618876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T00:00:00Z","timestamp":1618876800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic venous leg ulcer reduces the patients\u2019 activities and their overall quality of life. Platelet\u2010rich plasma (PRP) was previously investigated as promising less invasive management for leg ulcers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>This study aims<\/jats:title>\n                    <jats:p>To re\u2010assess the efficacy and safety of PRP in the management of chronic leg ulcers due to venous factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients\/Methods<\/jats:title>\n                    <jats:p>RCT enrolled 80 patients who clinically presented with chronic venous leg ulcers. Forty patients were allocated randomly for the treatment with autologous platelet\u2010rich plasma (PRP). Intradermal and subdermal injection of PRP by 27guage syringe weekly, in all edges and in the granular floor of the ulcer for 4\u20136 sessions. Another 40 patients managed by conventional treatment by compression and dressing for the same period were allocated as Group B. Objective assessment achieved by the percentage of reduction of the size of the ulcer area, rate of healing, incidence of recurrence, and if side effects have been reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      PRP therapy showed better results and high\n                      <jats:italic>p<\/jats:italic>\n                      value significance when compared to conventional therapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study shows that PRP is effective and significant in promoting the wound healing process in chronic leg venous ulcers. PRP is simple, safe, and has a short learning curve technique.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.14138","type":"journal-article","created":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T19:53:20Z","timestamp":1619034800000},"page":"3257-3263","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Objective assessment of Platelet\u2010Rich Plasma (PRP) potentiality in the treatment of Chronic leg Ulcer: RCT on 80 patients with Venous ulcer"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9238-1450","authenticated-orcid":false,"given":"Yasser","family":"Helmy","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Faculty of Medicine Al\u2010Azhar University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nehal","family":"Farouk","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery Faculty of Medicine (for Girls) Al\u2010Azhar University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmaa","family":"Ali Dahy","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Faculty of Medicine (for Girls) Al\u2010Azhar University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Abu\u2010Elsoud","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Faculty of Medicine (Assiut) Al\u2010Azhar University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rania","family":"Fouad khattab","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Faculty of Medicine (for Girls) Al\u2010Azhar University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar","family":"Elshahat Mohammed","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology Faculty of Medicine (for Girls) Al\u2010Azhar University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lamia","family":"Abdullbary Gad","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology Faculty of Medicine (for Girls) Al\u2010Azhar University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayman","family":"Altramsy","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Faculty of Medicine (for Girls) Al\u2010Azhar University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emad","family":"Hussein","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Faculty of Medicine (for Girls) Al\u2010Azhar University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayman","family":"Farahat","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Faculty of Medicine Al\u2010Azhar University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.111633"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2014.04.049"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1534734619870680"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/CWCMR.S118655"},{"issue":"4","key":"e_1_2_9_6_1","first-page":"333","article-title":"Platelet gel: a new therapeutic tool with great potential","volume":"15","author":"Piccin A","year":"2017","journal-title":"Blood Transfus"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.21608\/aimj.2021.52095.1368"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.21608\/aimj.2020.29351.1217"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.21608\/aimj.2021.49733.1351"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2004.09.027"},{"key":"e_1_2_9_11_1","first-page":"1","article-title":"Sheldon T Systematic reviews of wound care management: (3) antimicrobial agents for chronic wounds; (4) diabetic foot ulceration","volume":"4","author":"O'Meara S","year":"2000","journal-title":"Health Technol Assess"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/1534734606292429"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13250"},{"key":"e_1_2_9_14_1","first-page":"A76","article-title":"Autologous platelet\u2010rich fibrin matrix as a stimulator of healing of chronic lower extremity ulcers","volume":"14","author":"O'Connell SM","year":"2006","journal-title":"Wound Repair Regen"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2008.11.069"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12875-014-0211-8"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12777"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.01862.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000222526.21512.4c"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(03)00908-X"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.3.483"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0939-4753(04)80029-2"},{"key":"e_1_2_9_23_1","first-page":"36","article-title":"Chronic wounds treated with a physiologically relevant concentration of platelet\u2010rich plasma gel: A prospective case series","volume":"56","author":"Frykberg RG","year":"2010","journal-title":"Ostomy Wound Manage"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12401"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2077.112671"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.4103\/JCAS.JCAS_137_16"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13897"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13567"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13577"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21124404"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/2000656X.2020.1846544"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2019.28.1.15"},{"issue":"1","key":"e_1_2_9_33_1","first-page":"13","article-title":"Efficacy and safety of plasma rich in growth factors in the treatment of venous ulcers: a randomized clinical trial controlled with conventional treatment","volume":"3","author":"Aguirre JJ","year":"2015","journal-title":"Clinical Dermatol"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14138","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.14138","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14138","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:45:55Z","timestamp":1791506755000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.14138"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,20]]},"references-count":32,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1111\/jocd.14138"],"URL":"https:\/\/doi.org\/10.1111\/jocd.14138","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,20]]},"assertion":[{"value":"2021-02-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}