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The follow\u2010up study was carried out at 1, 3, 6, 12, and 24\u00a0months after treatment, and photographs and satisfactions questionnaire were collected and assessed. All volunteers were independently assessed by blinded evaluators using global aesthetic improvement scores (GAIS). One\u2010way Anova was used for statistical analysis, and the significant level was \u03b1=0.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The static forehead rhytides were improved observably after the treatment. It still showed good result even at month 24 after the injection. There are no severe adverse effects observed in the whole procedure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Autologous fibroblast and keratin combined injection might be an ideal therapy in\u00a0mini\u2010invasive plastic injection area, which is safe and effective for static forehead rhytides correction, and has a long\u2010term efficacy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.14163","type":"journal-article","created":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T06:17:27Z","timestamp":1618899447000},"page":"3308-3314","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A new treatment for static forehead rhytides: Autologous fibroblast and keratin injection"],"prefix":"10.1111","volume":"20","author":[{"given":"Bingqing","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Ear Reconstruction Plastic Surgery Hospital Chinese Academy of Medical Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Medical Technology and Engineering Zheng Zhou Railway vocational &amp; Technical College ZhengZhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Hematology The first Affiliated Hospital of Zhengzhou University Zheng Zhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ear Reconstruction Plastic Surgery Hospital Chinese Academy of Medical Sciences Beijing 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