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Phenotype\u2010based treatments and long\u2010term managements have also been recommended. Murine models are a powerful tool in unveiling and dissecting the mechanisms of human diseases. Here, we summarized murine models of rosacea developed or used in previous research, including LL\u201037 intradermal injection model, KLK\u20105\u2010induced inflammation model, croton oil inflammation model, 12\u2010O\u2010Tetradecanoylphorbol\u201013\u2010acetate inflammation model, arachidonic acid inflammation model, RTX\u2010induced vasodilation model, and UVB\u2010induced model. LL\u201037 injection model has become the most intensively used model in rosacea research. Each model could show the pathophysiological and clinical features of rosacea to some extent. However, no model can show the full picture of the characteristics of rosacea. Improving existed murine models, developing new murine models, and applying them to pathogenesis and treatment research on rosacea are highly warranted in the future.<\/jats:p>","DOI":"10.1111\/jocd.14164","type":"journal-article","created":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T01:22:16Z","timestamp":1618881736000},"page":"905-909","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Murine models of rosacea: a review"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5065-4086","authenticated-orcid":false,"given":"Hanlin","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Dermatology Peking Union Medical College Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menglu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Peking Union Medical College Hospital  Beijing 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