{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:52:11Z","timestamp":1791507131251,"version":"4.3.4"},"reference-count":6,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T00:00:00Z","timestamp":1619568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T00:00:00Z","timestamp":1619568000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Adverse effects from dermal fillers are uncommon. We report a case of filler\u2010induced xanthelasma at the bilateral infraorbital region in a 43\u2010year\u2010old woman after multiple injections of hyaluronic acid to correct tear trough depression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>We report a case of a 43\u2010year\u2010old woman with a chief complaint of skin discoloration of the bilateral lower eyelids. Her history was significant for ten sessions of hyaluronic acid filler for tear trough deformity between December 2008 and May 2016. On clinical examination, she exhibited thin, soft, and yellow papules to her lower medial infraorbital hollows. A punch biopsy showed foamy histiocytes with a background of hypervascularization and focal extracellular lipid in the superficial dermis, consistent with xanthelasma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Xanthelasma was treated with multiple passes of Er:YAG laser (Sciton Contour TRL) with a 4\u00a0mm spot size, fluence 7.5\u00a0J\/cm2, and ablate\/coagulate 50\/50 at 6\u00a0Hz until clearance occurred. The perilesional skin was treated with 1\u20132 passes, fluence 7.5\u00a0J\/cm2, ablate\/coagulate 50\/0 to blend in the cosmetic unit. Six\u2010month follow\u2010up showed notable improvement of all lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>There is a paucity of treatments described for filler\u2010induced xanthelasma reaction. While broad conclusions cannot be drawn from one case, our experience indicates that complete resolution can be achieved with Er:YAG ablation. We hypothesize that this laser is an optimal treatment, as it can vaporize the lipid contents while minimizing adverse effects, such as scars and hyperpigmentation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.14166","type":"journal-article","created":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T09:33:45Z","timestamp":1618997625000},"page":"3190-3192","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Lower eyelid xanthelasma following hyaluronic acid filler injections to the tear troughs"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5237-4878","authenticated-orcid":false,"given":"Annie","family":"Liu","sequence":"first","affiliation":[{"name":"Cosmetic Laser Dermatology: A West Dermatology Company San Diego CA USA"},{"name":"UCSD Dermatopathology\/Dermatology San Diego Health Systems University of California San Diego CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramya","family":"Kollipara","sequence":"additional","affiliation":[{"name":"Cosmetic Laser Dermatology: A West Dermatology Company San Diego CA USA"},{"name":"UCSD Dermatopathology\/Dermatology San Diego Health Systems University of California San Diego CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elika","family":"Hoss","sequence":"additional","affiliation":[{"name":"Cosmetic Laser Dermatology: A West Dermatology Company San Diego CA USA"},{"name":"UCSD Dermatopathology\/Dermatology San Diego Health Systems University of California San Diego CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchel P.","family":"Goldman","sequence":"additional","affiliation":[{"name":"Cosmetic Laser Dermatology: A West Dermatology Company San Diego CA USA"},{"name":"UCSD Dermatopathology\/Dermatology San Diego Health Systems University of California San Diego CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0000000000000722"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.11152.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000002208"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2005.10.008"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(94)70023-0"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3181c82f90"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14166","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.14166","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14166","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:46:14Z","timestamp":1791506774000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.14166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,28]]},"references-count":6,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1111\/jocd.14166"],"URL":"https:\/\/doi.org\/10.1111\/jocd.14166","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,28]]},"assertion":[{"value":"2020-06-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}