{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T22:28:09Z","timestamp":1783636089699,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T00:00:00Z","timestamp":1619654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with acne vulgaris continue to present increasingly in dermatology outpatient clinics and seek treatment during the COVID\u201019 pandemic. As far as we know, the effect of isotretinoin on COVID\u201019\u00a0has not been studied before.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>We aimed to evaluate whether patients receiving oral isotretinoin are at increased risk of COVID\u201019 infection by comparing them with patients on topical treatment for acne vulgaris.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The data were collected retrospectively from a cohort of 267 acne vulgaris patients, who were under follow\u2010up for acne vulgaris treatment during the pandemic period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Total of 227 patients (141 receiving isotretinoin treatment and 86 receiving topical treatment) were included of whom 29 patients had COVID\u201019 infection during acne vulgaris treatment. Fifteen (10.6%) patients were receiving oral isotretinoin and 14 (16.3%) were receiving topical acne treatment at the time of COVID\u201019 infection. The mean cumulative dose was 2340\u00a0\u00b1\u00a01988\u00a0mg at the time of COVID\u201019 infection. The mean elapsed time between the onset of isotretinoin treatment and positive PCR result for COVID\u201019 was 13.3\u00a0\u00b1\u00a010.3\u00a0weeks. Nine patients (64.3%) receiving isotretinoin treatment and 9 patients (60%) under topical treatment had loss of taste and smell during COVID\u201019 infection. Isotretinoin treatment was not found to be associated with a significant increased risk of getting COVID\u201019 (odds ratio, 0.671; 95% confidence interval, 0.247\u20131.823; <jats:italic>P<\/jats:italic>\u00a0\u00a0=\u00a00.434).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>As a conclusion, the results of this study encourage dermatologists and acne vulgaris patients to initiate oral isotretinoin treatment safely during the pandemic period.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14168","type":"journal-article","created":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T12:14:27Z","timestamp":1619093667000},"page":"1969-1974","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Oral isotretinoin treatment in patients with acne vulgaris during the COVID\u201019 pandemic: A retrospective cohort study in a tertiary care hospital"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5051-5481","authenticated-orcid":false,"given":"Neslihan","family":"Demirel \u00d6\u011f\u00fct","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology U\u015fak University Training and Research Hospital U\u015fak Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9665-015X","authenticated-orcid":false,"given":"\u00d6mer","family":"Kutlu","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology School of Medicine U\u015fak University U\u015fak Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ece","family":"Erba\u011fc\u0131","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology U\u015fak University Training and Research Hospital U\u015fak Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,29]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"World Health Organization. Statement on the second meeting of the International Health Regulations(2005)Emergency committee regarding the outbreak of novel coronavirus (2019\u2010nCoV).https:\/\/www.who.int\/news\/item\/30\u201001\u20102020\u2010statement\u2010on\u2010the\u2010second\u2010meeting\u2010of\u2010the\u2010international\u2010health\u2010regulations\u2010(2005)\u2010emergency\u2010committee\u2010regarding\u2010the\u2010outbreak\u2010of\u2010novel\u2010coronavirus\u2010(2019\u2010ncov). Accessed January 19 2021."},{"key":"e_1_2_9_3_1","unstructured":"World Health OrganizationWHO director\u2010general's opening remarks at the media briefing on COVID\u201019\u201011 March 2020.https:\/\/www.who.int\/director\u2010general\/speeches\/detail\/who\u2010director\u2010general\u2010s\u2010opening\u2010remarks\u2010at\u2010the\u2010media\u2010briefing\u2010on\u2010covid\u201019\u2010\u2010\u201011\u2010march\u20102020. Accessed January 19 2021."},{"key":"e_1_2_9_4_1","unstructured":"World Health OrganisationWHO coronavirus disease (COVID\u201019) dashboard.https:\/\/covid19.who.int. Accessed January 19 2021."},{"key":"e_1_2_9_5_1","unstructured":"Turkish Ministry of HealthGeneral coronavirus table.https:\/\/covid19.saglik.gov.tr\/EN\u201069532\/general\u2010coronavirus\u2010table.html. Accessed January 19 2021."},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.14485"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.14547"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.05.048"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2020.11.056"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.14096"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13581"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.12.037"},{"key":"e_1_2_9_13_1","unstructured":"British Association of Dermatologists.Guidance for managing patients on isotretinoin during the coronavirus pandemic.https:\/\/www.bad.org.uk\/shared\/get\u2010file.ashx?itemtype=document&id=6661. Accessed January 19 2021."},{"key":"e_1_2_9_14_1","unstructured":"American Academy of DermatologyTaking isotretinoin during the coronavirus pandemic.https:\/\/www.aad.org\/public\/diseases\/acne\/derm\u2010treat\/isotretinoin\/coronavirus\u2010pandemic. Accessed January 19 2021."},{"issue":"3","key":"e_1_2_9_15_1","first-page":"130","article-title":"Treatment of acne vulgaris","volume":"18","author":"James KW","year":"1958","journal-title":"GP"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13704"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13482"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2020.02.008"},{"issue":"4","key":"e_1_2_9_19_1","article-title":"Could patients taking isotretinoin therapy be immune against SARS\u2010CoV\u20102?","volume":"33","author":"Hamouda EL","year":"2020","journal-title":"Dermatol Ther"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1570"},{"key":"e_1_2_9_21_1","article-title":"(COVID\u201019): A retrospective analysis of adherence to therapy and side effects","volume":"2020","author":"Donnarumma M","year":"2019","journal-title":"Dermatol Ther"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyaa140"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599820934376"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00179013"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20175483"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14168","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.14168","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14168","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T18:11:34Z","timestamp":1709316694000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.14168"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,29]]},"references-count":24,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1111\/jocd.14168"],"URL":"https:\/\/doi.org\/10.1111\/jocd.14168","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,29]]},"assertion":[{"value":"2021-03-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}