{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T06:11:14Z","timestamp":1785305474593,"version":"3.55.0"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T00:00:00Z","timestamp":1622419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acanthosis nigricans (AN) is a common dermatological issue with several therapeutic modalities to treat. Despite retinoid is the first drug of choice in the treatment, the fractional\u2010ablative carbon dioxide (CO<jats:sub>2<\/jats:sub>) laser has revealed as a promising procedure for the management of neck\u2010AN, outstanding to its ability for superficial ablation of the skin surface, with trans\u2010epidermal melanin elimination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To decide whether fractional\u2010ablative CO<jats:sub>2<\/jats:sub> laser or retinoic acid (5%) peel is the more effective and safe choice for AN treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, twenty Egyptian cases with neck\u2010AN were enrolled, where each case was exposed to four sessions with 2\u00a0weeks apart of both fractional CO<jats:sub>2<\/jats:sub>\u00a0laser on the right half of the neck and retinoic acid peel on the left half of the neck. Cases were assessed by a scoring system: Acanthosis Nigricans Area and Severity Index (ANASI) score, two blinded dermatologists, and dermoscopically before and one month after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found a highly statistically significant improvement among both treated groups regarding (ANASI) score and dermatologist's assessments. Bedside, the degree of sulci cutis, cristae cutis, brown\u2010to\u2010dark brown dots, and milia\u2010like cysts, dermoscopic sign improvement was evident in both treated groups. However, fractional CO<jats:sub>2<\/jats:sub> laser shows the superior result to retinoic acid peel in the treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Fractional CO<jats:sub>2<\/jats:sub> laser and retinoic acid peel are considered effective modalities for neck\u2010AN treatment. However, fractional CO<jats:sub>2<\/jats:sub> laser was more effective.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14224","type":"journal-article","created":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T10:07:45Z","timestamp":1621246065000},"page":"1023-1030","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Comparative study between fractional carbon dioxide laser versus retinoic acid chemical peel in the treatment of acanthosis nigricans"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1550-6464","authenticated-orcid":false,"given":"Ayat A","family":"Abu Oun","sequence":"first","affiliation":[{"name":"Dermatology and Venereology Faculty of Medicine for Girls Al\u2010Azhar University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6225-0839","authenticated-orcid":false,"given":"Naglaa A.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Dermatology and Venereology Faculty of Medicine for Girls Al\u2010Azhar University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hala S.A.","family":"Hafiz","sequence":"additional","affiliation":[{"name":"Dermatology and Venereology Faculty of Medicine for Girls Al\u2010Azhar University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,31]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.15031"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2019.1708855"},{"issue":"5","key":"e_1_2_9_4_1","first-page":"4133","article-title":"Acanthosis nigricans: to be or not to be afraid","volume":"17","author":"Popa ML","year":"2019","journal-title":"Oncology letters"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-019-02944-9"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S137527"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-009-0734-8"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-018-2505-x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-16805-0"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2013.06.008"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2001.00202.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"crossref","unstructured":"KhungerN.Step by Step: Chemical Peels. JP Medical Ltd; 2014 Aug 31.","DOI":"10.5005\/jp\/books\/12232"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02542.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002380050260"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2011.23.1.95"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13544"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-61211-1.00046-2"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.201755325"},{"issue":"3","key":"e_1_2_9_19_1","first-page":"159","article-title":"Topical tretinoin in acanthosis nigricans","volume":"62","author":"Lahiri K","year":"1996","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.13799"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14224","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.14224","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14224","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T07:48:12Z","timestamp":1692776892000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.14224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,31]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1111\/jocd.14224"],"URL":"https:\/\/doi.org\/10.1111\/jocd.14224","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,31]]},"assertion":[{"value":"2021-04-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}