{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T17:49:19Z","timestamp":1792432159670,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T00:00:00Z","timestamp":1622764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Wound healing is among the frequent illnesses that affects the skin, and therefore, the screening of natural preparation to treat skin burn is important. <jats:italic>In Morocco, Cynara humilis<\/jats:italic> is a Moroccan medicinal plant widely used for the treatment of skin burn.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this study was to investigate the safety of <jats:italic>C.\u00a0humilis<\/jats:italic> and its wound healing potential against skin burn.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this work, <jats:italic>C.\u00a0humilis<\/jats:italic> was selected based on an ethnopharmacological survey. As revealed by traditional medicine, <jats:italic>C.\u00a0humilis<\/jats:italic> powder extract (CHPE) was used to test wound healing effects. Furthermore, to assure the safety of this powder, acute and subchronic dermal toxicities were investigated on animal models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The oral acute toxicity test of CHPE did not show mortality in treated rats (LD<jats:sub>50<\/jats:sub>&gt;2000\u00a0mg\/kg). Moreover, in the acute dermal toxicity, CHPE at 5\u00a0g\/kg did not induce clinical signs observed during the observation period of 48\u00a0h. In the subchronic toxicity test, CHPE did not cause significant abnormalities in the physiological parameters and pathological changes in the major organs of the rats. Body weight evolution and macroscopic analysis of skin burn showed CHPE exhibited important wound healing effects in a time\u2010dependent manner. CHPE reduced significantly wound surface (6.93\u00a0\u00b1\u00a00.25\u00a0cm<jats:sup>2<\/jats:sup>) compared with the SDA group (8.30\u00a0\u00b1\u00a00.37\u00a0cm<jats:sup>2<\/jats:sup>) and the no\u2010treated group (10.05\u00a0\u00b1\u00a00.28\u00a0cm<jats:sup>2<\/jats:sup>). Moreover, the retention rate was increased importantly after the treatment with CHPE (61.66\u00a0\u00b1\u00a01.42%) compared with the SDA\u2010treated group (53.57%\u00a0\u00b1\u00a02.83%) and the no\u2010treated group control animals (43.34%\u00a0\u00b1\u00a01.27%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results were confirmed by a histological evaluation, which showed that CHPE increased the neovascularization, the collagen deposition, and the re\u2010epithelialization. The findings of this work suggest that CHPE could be a promising source for developing drugs against skin burn.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14237","type":"journal-article","created":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T11:49:06Z","timestamp":1621424946000},"page":"1596-1609","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Investigation of wound healing activity <i>Cynara<\/i><i>humilis<\/i> of root extracts"],"prefix":"10.1111","volume":"21","author":[{"given":"Najoua","family":"Salhi","sequence":"first","affiliation":[{"name":"Pharmacoepidemiology and Pharmacoeconomics Research Team Laboratory of Pharmacology and Toxicology Faculty of Medicine and Pharmacy Mohammed V University in Rabat  Rabat Morocco"},{"name":"Pharmacodynamics Research Team ERP Laboratory of Pharmacology and Toxicology Faculty of Medicine and Pharmacy Mohammed V University in Rabat  Rabat 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Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mounia","family":"Bouabdellah","sequence":"additional","affiliation":[{"name":"Central laboratory of Biochemistry Ibn Sina Hospital  Rabat Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Layachi","family":"Chabraoui","sequence":"additional","affiliation":[{"name":"Central laboratory of Biochemistry Ibn Sina Hospital  Rabat Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6548-7823","authenticated-orcid":false,"given":"Gokhan","family":"Zengin","sequence":"additional","affiliation":[{"name":"Physiology and Biochemistry Research Laboratory Department of Biology Science Faculty Selcuk University  Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid","family":"Taghzouti","sequence":"additional","affiliation":[{"name":"Team of Animal Physiology and Physiopathology Department of Biology Faculty of Sciences, 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