{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T22:30:10Z","timestamp":1757457010701,"version":"3.40.5"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,6,12]],"date-time":"2021-06-12T00:00:00Z","timestamp":1623456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Psoriasis is a chronic, immune\u2010related disorder; inflammation, higher rate of epidermal proliferation, and angiogenesis are the main pathognomonic features. Cluster of differentiation 93 (CD93), an angiogenic element, plays a role in cell adhesion regulation and has a putative function in inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess CD93 immunohistochemical expression in psoriatic skin and the association of CD93 single nucleotide polymorphisms (SNPs) rs2749817 to disease pathogenesis and severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This case\u2010control study was done on 50 patients with psoriasis vulgaris beside 50 age\u2010 and sex\u2010matched healthy controls. Assessment of psoriasis severity was done by Psoriasis Area and Severity Index (PASI) score. 3\u00a0mm punch skin biopsies were taken from every participant, and hematoxylin and eosin staining and immunohistochemical staining for CD93 antibody were done. Assessment of CD93 rs2749817 gene polymorphism by the TaqMan allelic discrimination assay technique (real\u2010time PCR) was done.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Immunohistochemical expression of CD93 showed membrano\u2010cytoplasmic localization in both endothelial and inflammatory cells of cases and controls with significant more positivity in dermal endothelial and inflammatory cells of cases than controls (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.001 and 0.014 respectively). Strong intensity was present in 18 of cases endothelial cells and 24 inflammatory cells with absence in controls (<jats:italic>p<\/jats:italic>\u00a0=\u00a0\u20090.001 for both) with significantly higher H\u2010score and higher percent of positive cells (<jats:italic>p<\/jats:italic>\u00a0\u2009=\u00a0\u20090.001 for both).<\/jats:p><jats:p>The TC genotype was lower in patients compared to control (<jats:italic>p<\/jats:italic>\u2010value\u00a0=\u00a00.006) and CC genotype which was present only in cases (<jats:italic>p<\/jats:italic>\u2010value\u00a0=\u00a00.021).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cluster of differentiation 93 has an essential role in psoriasis and an encouraging future therapy for psoriasis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14250","type":"journal-article","created":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T11:35:30Z","timestamp":1621856130000},"page":"1616-1624","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["CD93 has a crucial role in pathogenesis of psoriasis"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7126-8261","authenticated-orcid":false,"given":"Wafaa Ahmed","family":"Shehata","sequence":"first","affiliation":[{"name":"Department of Dermatology, Andrology and STDs Faculty of Medicine\u2010 Menoufia University  Shebin El\u2010Kom Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alaa Hassan","family":"Maraee","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Andrology and STDs Faculty of Medicine\u2010 Menoufia University  Shebin El\u2010Kom Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nermin","family":"Tayel","sequence":"additional","affiliation":[{"name":"Molecular Diagnostics &amp; Therapeutics Molecular Diagnostics &amp; Therapeutics Department Genetic Engineering and Biotechnology Research Institute  Sadat City Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0869-6332","authenticated-orcid":false,"given":"Asmaa S.","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Medicine Menoufia University  Shebin El\u2010Kom Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eman M.","family":"Abd El Gayed","sequence":"additional","affiliation":[{"name":"Medical Biochemistry and Molecular Biology Department Menoufia University  Shebin El\u2010Kom Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nehad Badr Abd Elaty","family":"Elsayed","sequence":"additional","affiliation":[{"name":"Public Health and Community Medicine Faculty of Medicine Menoufia University  Shebin El\u2010Kom Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed I.","family":"Mostafa","sequence":"additional","affiliation":[{"name":"Clinical Pathology Department Medical Research Division National Research Centre  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6073-6170","authenticated-orcid":false,"given":"Heba A. S.","family":"Bazid","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Andrology and STDs Faculty of Medicine\u2010 Menoufia University  Shebin El\u2010Kom Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.03.037"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15021"},{"issue":"5","key":"e_1_2_10_4_1","first-page":"WC01","article-title":"Role of HCV infection in psoriasis: a clinical and immunohistochemical study","volume":"13","author":"Farag AG","year":"2019","journal-title":"J Clin Diagn Res"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010immunol\u2010032713\u2010120225"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.10.057"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05663"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2013.06.001"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555\u20102682"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051647"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521\u20104141(200105)31::5<1370:AID\u2010IMMU1370>3.0.CO;2\u2010B"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555\u20102227"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384\u2010015\u20102247\u20101"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100803"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13947"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.42\u20104\u2010405"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102796.2011.02364.x"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.1887"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14250","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.14250","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14250","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T11:01:21Z","timestamp":1692874881000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.14250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,12]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1111\/jocd.14250"],"URL":"https:\/\/doi.org\/10.1111\/jocd.14250","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"type":"print","value":"1473-2130"},{"type":"electronic","value":"1473-2165"}],"subject":[],"published":{"date-parts":[[2021,6,12]]},"assertion":[{"value":"2021-04-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}