{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T06:49:45Z","timestamp":1765176585987,"version":"3.40.5"},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T00:00:00Z","timestamp":1624233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Lichen planus disease is a chronic inflammatory disorder of mucosal and cutaneous tissues, and its etiology and pathogenesis are unclear. Cytokines have a significant role in the beginning, the maintenance of inflammatory and intercellular crosstalk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>We assessed serum levels of neutrophil activation marker (calprotectin) in patients with cutaneous lichen planus with different subtypes and made a comparison with healthy individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Method<\/jats:title><jats:p>Peripheral blood samples of 30 cases with lichen planus were compared with 30\u00a0healthy individuals. Serum samples were prepared from LP patients, using a commercial ELISA kit, and calprotectin level was measured in each serum sample.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The serum level of calprotectin was significantly raised in LP cases compared with control (141.34\u00a0\u00b1\u00a017.47\u00a0ng\/ml versus 40.03\u00a0\u00b1\u00a01.54\u00a0ng\/ml respectively; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). No correlation was recorded among of serum of calprotectin and patients\u2019 ages, sex, disease period, and the existence or strength of pruritus. But a strong positive correlation was present between the coexistence of oral lesions and the number of locations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Calprotectin can be used as a marker of Lichen planus severity and progression. Calprotectin may play a role in the pathogenesis of LP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14252","type":"journal-article","created":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T10:58:46Z","timestamp":1622113126000},"page":"1625-1628","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Estimation of neutrophil activation marker in lichen planus patients"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2600-4021","authenticated-orcid":false,"given":"Fathia M.","family":"Khattab","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology Faculty of Medicine Zagazig University  Zagazig Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rania","family":"Ghonaim","sequence":"additional","affiliation":[{"name":"Clinical Pathology Faculty of Medicine Zagazig University  Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mai A.","family":"Samir","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology Faculty of Medicine Zagazig University  Zagazig Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2334\/josnusd.49.89"},{"key":"e_1_2_8_3_1","first-page":"66","article-title":"Lichen planus. A review","volume":"74","author":"Anuradha CH","year":"2008","journal-title":"N Y State Dent J"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2009.03.004"},{"key":"e_1_2_8_5_1","first-page":"126","article-title":"Treatment of oral lichen planus with photodynamic therapy mediated methylene blue: a case report","volume":"11","author":"Aghahosseini F","year":"2006","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"e_1_2_8_6_1","first-page":"S25.e1","article-title":"Oral lichen planus and oral lichenoid lesions: diagnostic and therapeutic considerations","volume":"25","author":"Al\u2010Hashimi I","year":"2007","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endodontol"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/147973"},{"key":"e_1_2_8_8_1","first-page":"83","article-title":"Role of calprotectin in infection and inflammation","volume":"16","author":"Dhas DBB","year":"2012","journal-title":"Curr Pediatr Res"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1008647"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13574;oo:1\u20105"},{"issue":"1","key":"e_1_2_8_11_1","first-page":"3","article-title":"Possible involvement of a specific cell surface receptor for calprotect in induced apoptosis in colon adenocarcinoma and carcinam cell lines (SW742 and HT29\/219)","volume":"15","author":"Ghavami S","year":"2004","journal-title":"J Sci Islamic Repub Iran"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/1535370216681551"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/6521274"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsi.2014.08.003"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14252","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.14252","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14252","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T11:01:31Z","timestamp":1692874891000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.14252"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,21]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1111\/jocd.14252"],"URL":"https:\/\/doi.org\/10.1111\/jocd.14252","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"type":"print","value":"1473-2130"},{"type":"electronic","value":"1473-2165"}],"subject":[],"published":{"date-parts":[[2021,6,21]]},"assertion":[{"value":"2021-04-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}